Evidence map›Paper›PMID 36732332›Full record

ArticleNPJ vaccines2023

Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases.

Ruiying Wang, Lorena V N Oliveira, Diana Lourenco, Christina L Gomez, Chrono K Lee, Maureen M Hester, Zhongming Mou, Gary R Ostroff, Charles A Specht, Stuart M Levitz

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  10. Peripheral blood CD4The Journal of infection · 2025
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  12. State of the Field: Cytotoxic Immune Cell Responses inJournal of fungi (Basel, Switzerland) · 2024
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  15. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
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  16. Review
  17. Article
  18. Immune evasion byFrontiers in immunology · 2024
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ruiying Wang *Department of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-3638-4582
Lorena V N Oliveira *Department of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-1762-0076
Diana LourencoDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.
Christina L GomezDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chrono K LeeDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.
Maureen M HesterDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-2680-4854
Zhongming MouDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.
Gary R OstroffProgram in Molecular Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.
Charles A SpechtDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA. charles.specht@umassmed.edu.ORCID http://orcid.org/0000-0002-5749-3112
Stuart M LevitzDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA. stuart.levitz@umassmed.edu.ORCID http://orcid.org/0000-0002-3799-3064
University of Massachusetts Chan Medical School · US

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
ROLE OF MACROPHAGES IN CRYPTOCOCCAL INFECTIONSR01AI025780 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 1987 to 2019
$7.1M
Large Scale T Cell Epitope Discovery75N93019C00064 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAGE, KASIA · 2019 to 2024
$6.3M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Glucan Particles as a Vaccine Platform for Protective ImmunityR01AI102618 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 2013 to 2016
$2.1M
The contribution of eosinophils and the IL-23/IL-17 axis to host responses to AspergillusR01AI139615 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 2018 to 2021
$1.7M
NIAID NIH HHS 75N93019C00064NIAID NIH HHS R01 AI025780NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI102618NIAID NIH HHS R01 AI125045NIAID NIH HHS R01 AI139615NIAID NIH HHS R01 AI172154NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here, immunological correlates of vaccine-mediated protection were explored. Studies comparing knockout and wild-type mice demonstrated CD4

Identifiers

PMID36732332
PMCPMC9892683
OpenAlexW4319039817

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.