Evidence map›Paper›PMID 36732175›Full record

ReviewTrends in cognitive sciences2023

Sensing fear: fast and precise threat evaluation in human sensory cortex.

Wen Li, Andreas Keil

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  11. Competitive Cortical Prioritization Emerges for Trained Objects across the First Year of Life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
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  14. Stimulus Repetition Induces a Two-Stage Learning Process in the Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Article
  16. Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Wen LiDepartment of Psychology, Florida State University, Tallahassee, FL, USA. Electronic address: wenli@psy.fsu.edu.
Andreas KeilDepartment of Psychology, University of Florida, Gainsville, FL, USA.
Florida State University · USUniversity of Florida · US

Funding

MyAPS: Development and Validation of an AI Platform for Generating Emotional PicturesR01MH112558 · NIMH · UNIVERSITY OF FLORIDA · PI MINGZHOU DING, Ruogu Fang · 2017 to 2026
$2.5M
Ding R01 Administrative SupplementR01MH125615 · NIMH · UNIVERSITY OF FLORIDA · PI DING, MINGZHOU, KEIL, ANDREAS · 2021 to 2025
$2.5M
A Neurosensory Account of Posttraumatic Stress DisorderR01MH132209 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Wen Li · 2023 to 2026
$1.5M
Deficient inhibition underlies salience network hyperactivity in stress and anxietyR21MH126479 · NIMH · FLORIDA STATE UNIVERSITY · PI LI, WEN · 2022 to 2023
$425k
NIMH NIH HHS R01 MH112558NIMH NIH HHS R01 MH125615NIMH NIH HHS R01 MH132209NIMH NIH HHS R21 MH126479
6 · The paper itself

Abstract

Animal models of threat processing have evolved beyond the amygdala to incorporate a distributed neural network. In human research, evidence has intensified in recent years to challenge the canonical threat circuitry centered on the amygdala, urging revision of threat conceptualization. A strong surge of research into threat processing in the sensory cortex in the past decade has generated particularly useful insights to inform the reconceptualization. Here, synthesizing findings from both animal and human research, we highlight sensitive, specific, and adaptable threat representations in the sensory cortex, arising from experience-based sculpting of sensory coding networks. We thus propose that the human sensory cortex can drive smart (fast and precise) threat evaluation, producing threat-imbued sensory afferents to elicit network-wide threat responses.

Indexed as

AmygdalaFearAnimalsHumansParietal Lobeassociative plasticitylong-term memorylong-term storagesensory codingthreat conditioningthreat representations

Identifiers

PMID36732175
PMCPMC10023404
OpenAlexW4318681155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.