Evidence map›Paper›PMID 36732048›Full record

Observational studyArchives of disease in childhood. Fetal and neonatal edition2023

Antiseizure medication at discharge in infants with hypoxic-ischaemic encephalopathy: an observational study.

Elizabeth K Sewell, Seetha Shankaran, Scott A McDonald, Shannon Hamrick, Courtney J Wusthoff, Ira Adams-Chapman, Lina F Chalak, Alexis S Davis, Krisa Van Meurs, Abhik Das and 4 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Harnessing a neonatal encephalopathy registry for regional quality improvement efforts.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Reducing the percentage of surviving infants with acute symptomatic seizures discharged on anti-seizure medication.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Elizabeth K SewellPediatrics, Emory University School of Medicine, Atlanta, Georgia, USA elizabeth.sewell@emory.edu.ORCID http://orcid.org/0000-0003-3072-6569
Seetha ShankaranPediatrics Neonatology, Wayne State University Childrens Hospital of MI, Detroit, Michigan, USA.ORCID http://orcid.org/0000-0001-5512-9571
Scott A McDonaldRTI International, Research Triangle Park, North Carolina, USA.
Shannon HamrickPediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-6294-3480
Courtney J WusthoffChild Neurology, Stanford University, Palo Alto, California, USA.
Ira Adams-ChapmanPediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Lina F ChalakPediatrics, UT Southwestern Dallas, dallas, Texas, USA.ORCID http://orcid.org/0000-0001-5496-3257
Alexis S DavisPediatrics, Stanford University, Palo Alto, California, USA.
Krisa Van MeursDivision of Neonatology, Lucile Packard Children's Hospital, Palo Alto, California, USA.
Abhik DasRTI International, Rockville, Maryland, USA.ORCID http://orcid.org/0000-0003-2722-0479
Nathalie MaitrePediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Abbott LaptookPediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, USA.
Ravi Mangal PatelPediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-7444-5550
National Institute of Child Health and Human Development Neonatal Research Network
Emory University · USPalo Alto University · USRTI International · USLucile Packard Children's Hospital · USThe University of Texas Southwestern Medical Center · USWayne State University · USWomen & Infants Hospital of Rhode Island · US

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
ZIDOVUDINE &LAMIVUDINE ALONE OR IN COMBINATION ON BODY COMPOSITIONM01RR000054 · NCRR · TUFTS MEDICAL CENTER · PI MENON, VANDANA · 1985 to 2005
$12.2M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR000442NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001117NCRR NIH HHS M01 RR000032NCRR NIH HHS M01 RR000054NCRR NIH HHS M01 RR016587NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD068244NICHD NIH HHS U10 HD068263NICHD NIH HHS U10 HD068270NICHD NIH HHS U10 HD068278NICHD NIH HHS U10 HD068284NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068278
6 · The paper itself

Abstract

objectivesTo assess variability in continuation of antiseizure medication (ASM) at discharge and to evaluate if continuation of ASM at discharge is associated with death or disability among infants with hypoxic-ischaemic encephalopathy (HIE) and seizures.

designRetrospective study of infants enrolled in three National Institute of Child Health and Human Development Neonatal Research Network Trials of therapeutic hypothermia.

setting22 US centres. PATIENTS: Infants with HIE who survived to discharge and had clinical or electrographic seizures treated with ASM. EXPOSURES: ASM continued or discontinued at discharge. OUTCOMES: Death or moderate-to-severe disability at 18-22 months, using trial definitions. Multivariable logistic regression evaluated the association between continuation of ASM at discharge and the primary outcome, adjusting for severity of HIE, hypothermia trial treatment arm, use of electroencephalogram, discharge on gavage feeds, Apgar Score at 5 min, birth year and centre.

resultsOf 302 infants included, 61% were continued on ASMs at discharge (range 13%-100% among 22 centres). Electroencephalogram use occurred in 92% of the cohort. Infants with severe HIE comprised 24% and 22% of those discharged with and without ASM, respectively. The risk of death or moderate-to-severe disability was greater for infants continued on ASM at discharge, compared with those infants discharged without ASM (44% vs 28%, adjusted OR 2.14; 95% CI 1.13 to 4.05).

conclusionsIn infants with HIE and seizures, continuation of ASM at discharge varies substantially among centres and may be associated with a higher risk of death or disability at 18-22 months of age.

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainChildHumansInfantInfant, NewbornLogistic ModelsPatient DischargeRetrospective StudiesSeizuresInfant DevelopmentIntensive Care Units, NeonatalNeonatologyNeurology

Identifiers

PMID36732048
PMCPMC10293046
OpenAlexW4318973045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.