ArticleArchives of disease in childhood. Fetal and neonatal edition2023
Late-onset sepsis in very preterm infants in Norway in 2009-2018: a population-based study.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A systematic review of Perinatal Antibiotic Stewardship - where we are, where to go?Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study.European journal of pediatrics · 2026Article
- Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late-Onset Sepsis Accounted for Most Cases and Antibiotic Use.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Epidemiology, microbiological profile, and antimicrobial resistance patterns of culture-proven neonatal sepsis in a tertiary NICU.BMC pediatrics · 2026Article
- The gut-lung axis in early life: microbiome-associated mechanisms and clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- CoNS blood culture isolates from very preterm infants: antibiotic susceptibility, synergy testing andJAC-antimicrobial resistance · 2026Article
- Antimicrobial resistance and treatment mismatch in culture-proven sepsis among very preterm infants in Chinese NICUs: a cohort study.The Lancet regional health. Western Pacific · 2026Article
- Retrospective Study of Pathogen Distribution and Antimicrobial Resistance in 283 Neonates with Bloodstream Infections at a Grade-A Tertiary Hospital in China, 2021-2024.Infection and drug resistance · 2026Article
- Hospital Admissions After Early-Onset Neonatal Bacterial Infection Management Guidelines in France.JAMA network open · 2025Article
- Intrauterine inflammation exposure may increase the risk of late-onset sepsis in premature infants: a retrospective cohort study.Italian journal of pediatrics · 2025Article
- Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction.International journal of molecular sciences · 2025Article
- Epidemiology and Outcomes of Late-Onset Neonatal Sepsis in Preterm Infants in a Tertiary Hospital.Children (Basel, Switzerland) · 2025Article
- Efficacy of Enhanced Environmental Cleaning/Disinfection Using Pulsed Xenon Ultraviolet Light in Preventing Outbreaks of Methicillin-ResistantEpidemiologia (Basel, Switzerland) · 2025Article
- Probiotics and the Risk of Infection.Clinics in perinatology · 2025Review
- Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants.JAMA network open · 2024Article
- A decade of neonatal sepsis in Stockholm, Sweden: Gram-positive pathogens were four times as common as Gram-negatives.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.The Journal of antimicrobial chemotherapy · 2024Article
- Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation.Progress in retinal and eye research · 2024Review
- Less is more: Antibiotics at the beginning of life.Nature communications · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate epidemiology and outcomes among very preterm infants (<32 weeks' gestation) with culture-positive and culture-negative late-onset sepsis (LOS).
designCohort study using a nationwide, population-based registry.
setting21 neonatal units in Norway.
participantsAll very preterm infants born 1 January 2009-31 December 2018 and admitted to a neonatal unit.
main outcome measuresIncidences, pathogen distribution, LOS-attributable mortality and associated morbidity at discharge.
resultsAmong 5296 very preterm infants, we identified 582 culture-positive LOS episodes in 493 infants (incidence 9.3%) and 282 culture-negative LOS episodes in 282 infants (incidence 5.3%). Extremely preterm infants (<28 weeks' gestation) had highest incidences of culture-positive (21.6%) and culture-negative (11.1%) LOS. The major causative pathogens were coagulase-negative staphylococci (49%),
conclusionsLOS contributes to a significant burden of disease in very preterm infants and is associated with increased odds of severe BPD, cPVL and severe ROP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.