Evidence map›Paper›PMID 36731370›Full record

ArticleJournal of inorganic biochemistry2023

Conformational heterogeneity suggests multiple substrate binding modes in CYP106A2.

Nathan R Wong, Reethy Sundar, Sophia Kazanis, Jeetayu Biswas, Thomas C Pochapsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Correlating enzymatic reactivity for different substrates using transferable data-driven collective variables.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nathan R WongDept. of Biochemistry, Brandeis University, 415 South St., Waltham, MA 02454, United States of America.
Reethy SundarDept. of Biochemistry, Brandeis University, 415 South St., Waltham, MA 02454, United States of America.
Sophia KazanisDept. of Chemistry, Brandeis University, MS 015, 415 South St., Waltham, MA 02454, United States of America; Middlesex Community College, 33 Kearney Sq., Lowell, MA 01852, United States of America.
Jeetayu BiswasDept. of Chemistry, Brandeis University, MS 015, 415 South St., Waltham, MA 02454, United States of America; Department of Medicine, Weill-Cornell Medicine, New York, NY, United States of America.
Thomas C PochapskyDept. of Biochemistry, Brandeis University, 415 South St., Waltham, MA 02454, United States of America; Dept. of Chemistry, Brandeis University, MS 015, 415 South St., Waltham, MA 02454, United States of America; Rosenstiel Center for Basic Biomedical Research, Brandeis University, 415 South St., Waltham, MA 02454, United States of America. Electronic address: pochapsk@brandeis.edu.
Brandeis University · USCornell University · USMiddlesex Community College · US

Funding

Macromolecular Structure MechanismT32GM007596 · NIGMS · BRANDEIS UNIVERSITY · PI OPRIAN, DANIEL D · 1985 to 2019
$4.5M
STRUCTURE AND DYNAMICS OF METAL-CONTAINING PROTEINSR01GM044191 · NIGMS · BRANDEIS UNIVERSITY · PI POCHAPSKY, THOMAS CHARLES · 1995 to 2012
$3.4M
Structure and dynamics of clinically-relevant cytochrome P450 enzymes - Summer undergraduate research experience supplementR01GM130997 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POCHAPSKY, THOMAS CHARLES, SCOTT, EMILY E · 2019 to 2022
$1.8M
NIGMS NIH HHS R01 GM044191NIGMS NIH HHS R01 GM130997NIGMS NIH HHS T32 GM007596
6 · The paper itself

Abstract

CYP106A2 (cytochrome P450

Indexed as

Cytochrome P-450 Enzyme SystemSteroidsBacterial ProteinsHydroxylationMagnetic Resonance SpectroscopyModels, MolecularMolecular ConformationSubstrate SpecificityBacterial ProteinsCytochrome P-450 Enzyme SystemSteroidsCytochrome P450Enzyme conformationsNuclear magnetic resonanceParamagnetismRegiochemistryStereochemistrySubstrate

Identifiers

PMID36731370
PMCPMC9992128
OpenAlexW4319061359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.