Evidence map›Paper›PMID 36730373›Full record

ArticleCornea2023

Recurrent Keratoconus: Corneal Transplants for Keratoconus Develop Tomographic Ectatic Changes.

Maria Miura, Pia Leon, Yoav Nahum, Myriam S Böhm, Michael Mimouni, Michael W Belin, Lynette Johns, Joseph B Ciolino

Abstract read
In one paragraph

Article in Cornea, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Maria MiuraSchepens Eye Research Institution, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Pia LeonSchepens Eye Research Institution, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Yoav NahumDepartment of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.
Myriam S BöhmSchepens Eye Research Institution, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Michael MimouniSackler faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Michael W BelinOphthalmology & Vision Science, University of Arizona, Marana, AZ.
Lynette JohnsSchepens Eye Research Institution, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Joseph B CiolinoSchepens Eye Research Institution, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
Massachusetts Eye and Ear Infirmary · USTel Aviv University · ILHarvard University · US

Funding

CORNEAL STROMAL-EPITHELIAL INTERACTIONS DURING REPAIRR01EY005665 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Joseph B. Ciolino · 1985 to 2026
$14.4M
Antibiotic eluting contact lenses for the treatment of bacterial keratitisR01EY026640 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI CIOLINO, JOSEPH B. · 2017 to 2020
$2.0M
NEI NIH HHS R01 EY005665NEI NIH HHS R01 EY026640
6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate postoperative Scheimpflug imaging changes during the first 5 years after penetrating keratoplasty (PK) in patients with keratoconus (KC).

methodsThis retrospective, interventional case series includes 31 eyes of 31 patients who underwent their first PK with a history of KC. Postoperative Scheimpflug imaging was performed 3 months after the removal of the last suture (baseline) and then repeated 3 and 5 years after the PK. Demographic data, donor and host trephination diameter, and Scheimpflug imaging (Pentacam HR, Oculus, Germany) parameters indicative of ectasia were analyzed to evaluate postoperative graft changes that occur after PK.

resultsThe maximal keratometry (Kmax) progressed significantly between baseline (53.5 ± 6.1 D) and postoperative year 3 and year 5 [56.5 ± 6.1 diopter (D) and 58.8 ± 7.9 D, P < 0.001]. Significant changes were also observed for the anterior best fit sphere and posterior best fit sphere ( P < 0.001 for 3 and 5 years compared with baseline). Kmax increased by at least 2 Ds for 74.2% of patients and up to 7 Ds or more for 25.8% of the patients. A significant inverse correlation was observed for host trephine size and progression of Kmax (r = -0.52, P = 0.01), which indicated that larger host trephination size was associated with a smaller increase in postoperative Kmax.

conclusionsTomographic graft changes indicative of ectasia were observed within 3 to 5 years after PK in patients with KC. These changes were observed more frequently and sooner after corneal transplants than previously reported.

Indexed as

KeratoconusCorneaCorneal TopographyDilatation, PathologicHumansKeratoplasty, PenetratingRetrospective Studies

Identifiers

PMID36730373
PMCPMC13629610
OpenAlexW4318967538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.