Evidence map›Paper›PMID 36730336›Full record

ArticlePloS one2023

Micronutrients and cognitive functions among urban school-going children and adolescents: A cross-sectional multicentric study from India.

Shweta Singh, Shally Awasthi, Divas Kumar, Seema Rani Sarraf, Anuj Kumar Pandey, Girdhar G Agarwal, Avivar Awasthi, Anish T S, Joseph L Mathew, Sonali Kar and 11 more

Abstract readMulticenter Study
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shweta SinghDepartment of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Shally AwasthiDepartment of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.ORCID 0000-0003-1254-9802
Divas KumarDepartment of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
Seema Rani SarrafDepartment of Psychiatry, King George's Medical University, Lucknow, Uttar Pradesh, India.
Anuj Kumar PandeyDepartment of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
Girdhar G AgarwalDepartment of Statistics, University of Lucknow, Lucknow, Uttar Pradesh, India.
Avivar AwasthiDepartment of Endocrinology, Medical College, Kolkata, India.
Anish T SDepartment of Community Medicine, Government Medical College, Thiruvananthapuram, Kerela, India.
Joseph L MathewDepartment of Pediatric Medicine, Post Graduate Institute of Medical Sciences, Chandigarh, India.
Sonali KarDepartment of Community Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Orissa, India.
Suma NairDepartment of Community Medicine, Kasturba Medical College, Manipal, Karnataka, India.ORCID 0000-0002-1843-075X
Chythra R RaoDepartment of Community Medicine, Kasturba Medical College, Manipal, Karnataka, India.ORCID 0000-0002-4016-2683
Harsh PandeDepartment of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
B N MahantaDepartment of Medicine, Assam Medical College, Dibrugarh, Assam, India.
Bhavneet BhartiDepartment of Pediatric Medicine, Post Graduate Institute of Medical Sciences, Chandigarh, India.
C M SinghDepartment of Community & Family Medicine, All India Institute of Medical Sciences, Patna, Bihar, India.
Kuldeep SinghDepartment of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.ORCID 0000-0002-9375-3233
Mushtaq A BhatDepartment of Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.
Somashekar A RDepartment of Pediatrics, M. S. Ramaiah Institute of Medical Sciences, Bangalore, Karnataka, India.
Rajiv AwasthiPrarthana Diabetic Care Centre, Lucknow, Uttar Pradesh, India.
Abbas Ali MahdiDepartment of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicronutrient deficiency (MD) is associated with deficits in cognitive functioning of children. However, no comprehensive multicentric study has been conducted in India to explore the role of multiple MD in cognition of children and adolescents. The present study aimed to explore association of MD with level of general intelligence and specific cognitive functions, in urban school-going children and adolescents across ten cities of India.

methodCross-sectional multicentric study, enrolled participants aged 6-16 years. Blood samples were collected for biochemical analysis of calcium, iron, zinc, selenium, folate, vitamin A, D and B12. Colored Progressive Matrices / Standard Progressive Matrices (CPM/SPM), Coding, Digit Span and Arithmetic tests were used for the assessment of cognitive functions of participants. Height and weight measures were collected along with socio-economic status.

resultsFrom April-2019 to February-2020, 2428 participants were recruited from 60 schools. No MD was found in 7.0% (134/1918), any one MD in 23.8% (457/1918) and ≥ 2 MD in 69.2% (1327/1918) participants. In presence of ≥ 2 MD, adjusted odds ratio (OR) for borderline or dull normal in CPM/SPM was 1.63, (95% CI: 1.05-2.52), coding was 1.66 (95% CI: 1.02-2.71), digit span was 1.55 (95% CI: 1.06-2.25) and arithmetic was 1.72 (95% CI: 1.17-2.53), controlling for gender, socioeconomic status and anthropometric indicators.

conclusionSince ≥ 2 MD were found in more than 2/3rd of participants and was associated with impairment in cognitive function, attempts must be made to ameliorate them on priority in school going children in India. TRIAL REGISTRATION NUMBER: CTRI/2019/02/017783.

Indexed as

CognitionMicronutrientsAdolescentChildCross-Sectional StudiesFolic AcidHumansIndiaNutritional StatusSchoolsFolic AcidMicronutrients

Identifiers

PMID36730336
PMCPMC9894395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.