Observational studyPloS one2023
Feasibility of a wearable inertial sensor to assess motor complications and treatment in Parkinson's disease.
Observational study in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Wearable Sensors in Gait Assessment for Parkinson Disease and Stroke in Real-World Environments: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- The Usefulness of Wearable Sensors for Detecting Freezing of Gait in Parkinson's Disease: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Continuous Movement Monitoring at Home Through Wearable Devices: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- A Stand-Alone Wearable Measurement System for Continuous Hand Tremor Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Motor and non-motor fluctuations in Parkinson's disease: the knowns and unknowns of current therapeutic approaches.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Similarity Gait Networks with XAI for Parkinson's Disease Classification: A Pilot Study.Bioengineering (Basel, Switzerland) · 2026Article
- Consensus on the clinical utility of digital mobility outcomes for personalized clinical decision support in parkinson's disease.Neurological research and practice · 2025Article
- Wearables research for continuous monitoring of patient outcomes: A scoping review.PLOS digital health · 2025Article
- Test, track, treat using wearable sensors for management of Parkinson's disease: 12‑month prospective observational United Arab Emirates study using Parkinson's Kinetograph (EmPark-PKG Study).Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Comparison of clinical measures of motor function with a Holter monitor in Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Improving Parkinson's disease management through wearable technology: A cost-benefit perspective.PloS one · 2025Article
- Assessing the clinical utility of inertial sensors for home monitoring in Parkinson's disease: a comprehensive review.NPJ Parkinson's disease · 2024Article
- Tapered cross-linked ZnO nanowire bundle arrays on three-dimensional graphene foam for highly sensitive electrochemical detection of levodopa.Mikrochimica acta · 2024Article
- Unveiling the Unpredictable in Parkinson's Disease: Sensor-Based Monitoring of Dyskinesias and Freezing of Gait in Daily Life.Bioengineering (Basel, Switzerland) · 2024Article
- Wearable sensor devices can automatically identify the ON-OFF status of patients with Parkinson's disease through an interpretable machine learning model.Frontiers in neurology · 2024Article
- Overview on wearable sensors for the management of Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Clinical Evaluation in Parkinson's Disease: Is the Golden Standard Shiny Enough?Sensors (Basel, Switzerland) · 2023Article
- Holter STAT-ON™ against other tools for detecting MF in advanced Parkinson's disease: an observational study.Frontiers in neurology · 2023Article
- Need for personalized monitoring of Parkinson's disease: the perspectives of patients and specialized healthcare providers.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWearable sensors-based systems have emerged as a potential tool to continuously monitor Parkinson's Disease (PD) motor features in free-living environments.
objectivesTo analyse the responsivity of wearable inertial sensor (WIS) measures (On/Off-Time, dyskinesia, freezing of gait (FoG) and gait parameters) after treatment adjustments. We also aim to study the ability of the sensor in the detection of MF, dyskinesia, FoG and the percentage of Off-Time, under ambulatory conditions of use.
methodsWe conducted an observational, open-label study. PD patients wore a validated WIS (STAT-ONTM) for one week (before treatment), and one week, three months after therapeutic changes. The patients were analyzed into two groups according to whether treatment changes had been indicated or not.
resultsThirty-nine PD patients were included in the study (PD duration 8 ± 3.5 years). Treatment changes were made in 29 patients (85%). When comparing the two groups (treatment intervention vs no intervention), the WIS detected significant changes in the mean percentage of Off-Time (p = 0.007), the mean percentage of On-Time (p = 0.002), the number of steps (p = 0.008) and the gait fluidity (p = 0.004). The mean percentage of Off-Time among the patients who decreased their Off-Time (79% of patients) was -7.54 ± 5.26. The mean percentage of On-Time among the patients that increased their On-Time (59% of patients) was 8.9 ± 6.46. The Spearman correlation between the mean fluidity of the stride and the UPDRS-III- Factor I was 0.6 (p = <0.001). The system detected motor fluctuations (MF) in thirty-seven patients (95%), whilst dyskinesia and FoG were detected in fifteen (41%), and nine PD patients (23%), respectively. However, the kappa agreement analysis between the UPDRS-IV/clinical interview and the sensor was 0.089 for MF, 0.318 for dyskinesia and 0.481 for FoG.
conclusionsIt's feasible to use this sensor for monitoring PD treatment under ambulatory conditions. This system could serve as a complementary tool to assess PD motor complications and treatment adjustments, although more studies are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.