Evidence map›Paper›PMID 36730206›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery.

Alireza Ghanbarpour, Xue Fei, Tania A Baker, Joseph H Davis, Robert T Sauer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  11. Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Protein degradation by a component of the chaperonin-linked protease ClpP.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Review
  15. Dual function of LapB (YciM) in regulatingProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. A proteolytic AAA+ machine poised to unfold a protein substrate.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alireza GhanbarpourDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-7485-029X
Xue FeiDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-3378-7447
Tania A BakerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-0737-3411
Joseph H DavisDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-8858-8907
Robert T SauerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-1719-5399
Massachusetts Institute of Technology · US

Funding

Sequence Determinants of Protein Structure and StabilityR01GM101988 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2012 to 2019
$3.5M
Tools to determine and analyze the structures of molecular machines in motionR01GM144542 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Joseph Davis · 2022 to 2026
$1.6M
Structure and function of ClpXPR35GM141517 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2021 to 2024
$1.5M
NIGMS NIH HHS R01 GM101988NIGMS NIH HHS R01 GM144542NIGMS NIH HHS R35 GM141517
6 · The paper itself

Abstract

Energy-dependent protein degradation by the AAA+ ClpXP protease helps maintain protein homeostasis in bacteria and eukaryotic organelles of bacterial origin. In

Indexed as

Carrier ProteinsEscherichia coli ProteinsAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesEndopeptidase ClpEscherichia coliRNA, BacterialSubstrate SpecificityAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesCarrier ProteinsEndopeptidase ClpEscherichia coli ProteinsRNA, BacterialsspB protein, E colitmRNAAAA+ proteasesadaptor-mediated proteolysiscryo-EM structuretethering adaptors

Identifiers

PMID36730206
PMCPMC9963277
OpenAlexW4318916036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.