Evidence map›Paper›PMID 36730190›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.

Blaine Connor, Guillermo Moya-Alvarado, Naoya Yamashita, Rejji Kuruvilla

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Blaine ConnorDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0003-0214-8140
Guillermo Moya-AlvaradoDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-1948-2156
Naoya YamashitaDepartment of Applied Bioscience, Kanagawa Institute of Technology, Atsugi 243-0292, Japan.ORCID 0000-0001-7667-5264
Rejji KuruvillaDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-2851-675X
Johns Hopkins University · USKanagawa Institute of Technology · JP

Funding

Coupled axonal protein synthesis and lipidation in axon growth and homeostasisR01NS114478 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2020 to 2024
$2.2M
Neurotrophic factor trafficking and signaling in development and diseaseR01NS107342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2019 to 2022
$1.7M
Axon Transport of TrkA receptors in sympathetic neuronsF31NS113480 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CONNOR, BLAINE · 2019 to 2021
$122k
NINDS NIH HHS F31 NS113480NINDS NIH HHS R01 NS107342NINDS NIH HHS R01 NS114478
6 · The paper itself

Abstract

In neurons, many membrane proteins, synthesized in cell bodies, must be efficiently delivered to axons to influence neuronal connectivity, synaptic communication, and repair. Previously, we found that axonal targeting of TrkA neurotrophin receptors in sympathetic neurons occurs via an atypical transport mechanism called transcytosis, which relies on TrkA interactions with PTP1B, a protein tyrosine phosphatase. Here, we generated TrkA

Indexed as

NeuronsReceptor, trkAAnimalsAxonsMiceReceptors, Nerve Growth FactorSympathetic Nervous SystemTranscytosisReceptors, Nerve Growth FactorReceptor, trkAaxon transportPTP1B tyrosine phosphatasesympathetic neuron developmenttranscytosisTrkA receptors

Identifiers

PMID36730190
PMCPMC9963894
OpenAlexW4318929558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.