Evidence map›Paper›PMID 36729914›Full record

ArticleGut microbes

Dysregulation of CD177

Huimin Chen, Xiaohan Wu, Ruicong Sun, Huiying Lu, Ritian Lin, Xiang Gao, Gengfeng Li, Zhongsheng Feng, Ruixin Zhu, Yao Yao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. CD177Cellular and molecular life sciences : CMLS · 2026
    Article
  2. Article
  3. Neutrophil extracellular traps released by CD177Cell communication and signaling : CCS · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. The gasdermin family: emerging therapeutic targets in diseases.Signal transduction and targeted therapy · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Huimin ChenCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0002-4959-4327
Xiaohan WuCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ruicong SunCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Huiying LuCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ritian LinCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xiang GaoCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Gengfeng LiCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Zhongsheng FengCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ruixin ZhuDepartment of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Yao YaoDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Baisui FengDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhanju LiuCenter for Inflammatory Bowel Disease Research, The Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0002-0326-543X
Tongji University · CNSecond Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils synergize with intestinal resident intraepithelial lymphocytes (IELs) to serve as the first-line defense and maintain intestinal homeostasis. However, the underlying mechanisms whereby neutrophils regulate IELs to inhibit intestinal inflammation are still not completely understood. Here, we found that depletion of neutrophils (especially CD177

Indexed as

Gastrointestinal MicrobiomeIntraepithelial LymphocytesAnimalsDimethyl FumarateDysbiosisInflammationIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutNeutrophilsDimethyl FumarateCD177dimethyl fumarateintestinal inflammationintraepithelial lymphocytesNeutrophils

Identifiers

PMID36729914
PMCPMC9897772
OpenAlexW4318917836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.