Evidence map›Paper›PMID 36729363›Full record

ArticleObesity surgery2023

Analysis of the Efficacy and the Long-term Metabolic and Nutritional Status of Sleeve Gastrectomy with Transit Bipartition Compared to Roux-en-Y Gastric Bypass in Obese Rats.

Clement Baratte, Alexandra Willemetz, Lara Ribeiro-Parenti, Claire Carette, Simon Msika, Andre Bado, Sebastien Czernichow, Maude Le Gall, Tigran Poghosyan

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In one paragraph

Article in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Clement BaratteUniversité de Paris Cité, F-75015, Paris, France.
Alexandra WillemetzUniversité de Paris Cité, F-75015, Paris, France.
Lara Ribeiro-ParentiUniversité de Paris Cité, F-75015, Paris, France.
Claire CaretteUniversité de Paris Cité, F-75015, Paris, France.
Simon MsikaUniversité de Paris Cité, F-75015, Paris, France.
Andre BadoUniversité de Paris Cité, F-75015, Paris, France.
Sebastien CzernichowUniversité de Paris Cité, F-75015, Paris, France.
Maude Le GallUniversité de Paris Cité, F-75015, Paris, France.
Tigran PoghosyanUniversité de Paris Cité, F-75015, Paris, France. tigran.poghosyan@aphp.fr.ORCID http://orcid.org/0000-0002-7103-1088
Inserm · FRUniversité Claude Bernard Lyon 1 · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSleeve gastrectomy with transit bipartition (SG-TB) could be an attractive alternative to Roux-en-Y gastric bypass (RYGB) on weight loss and improvement of comorbidities in patients with obesity. However, there is little long-term data. Translational research on a rat model could allow long-term projection to assess efficacy and safety of SG-TB. The aim of this research was to evaluate the long-term efficacy and safety of SG-TB compared to RYGB and SHAM in rat model. MATERIALS AND

methodsNinety-four male obese Wistar rats were distributed into 3 groups: SG-TB (n = 34), RYGB (n = 32), and SHAM (control group, n = 28). The percentage of total weight loss (%TWL), coprocalorimetry, glucose and insulin tolerance test, insulin, GLP-1, PYY, and GIP before and after surgery were assessed. The animals were followed over 6 months (equivalent to 16 years in humans).

resultsAt 6 months, %TWL was significantly greater(p = 0.025) in the SG-TB group compared to the RYGB group. There was no difference between the groups (p = 0.86) in malabsorption 15 and 120 days postoperatively. Glucose tolerance was significantly improved (p = 0.03) in the SG-TB and RYGB groups compared to the preoperative state. Insulin secretion, at 3 months, was significantly more important in the SG-TB group (p = 0.0003), compared to the RYGB and SHAM groups. GLP-1 secretion was significantly increased in the SG-TB and RYGB groups compared to the preoperative state (p = 0.001) but similar between SG-TB and RYGB animals (p = 0.72).

conclusionIn a rat model, at long term compared to RYGB, SG-TB provides greater and better-maintained weight loss and an increased insulin secretion without impairing nutritional status.

Indexed as

Gastric BypassObesity, MorbidAnimalsGastrectomyGlucagon-Like Peptide 1GlucoseHumansInsulinMaleNutritional StatusObesityRatsRats, WistarRetrospective StudiesTreatment OutcomeWeight LossGlucagon-Like Peptide 1GlucoseInsulinBariatric surgeryRodent modelRoux-en-Y gastric bypassSleeve gastrectomy with transit bipartitionTranslational model

Identifiers

PMID36729363
OpenAlexW4318913765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.