ReviewMolecular diagnosis & therapy2023
Smelling the Disease: Diagnostic Potential of Breath Analysis.
Review in Molecular diagnosis & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Diagnostic Accuracy of Breath Tests to Detect Pulmonary Tuberculosis: A Systematic Review.Lung · 2025Pooled it
- Respirator-integrated continuous gas sampling for broadband optical spectroscopy.Scientific reports · 2026Article
- Integration of Federated Learning and Blockchain in Health Care: Tutorial on Medical Data, Architectures, Privacy, Security, and Regulatory Compliance.Journal of medical Internet research · 2026Article
- Evaluating the VOCORDER device for early disease detection through breath analysis: study protocol for a two-phase clinical study.BMJ open · 2026Article
- Real-Time Breath Diagnostics: Linking Molecular Pathways, Measurement Technologies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Harnessing breath biomarkers for pneumonia diagnosis and prognosis.Expert review of respiratory medicine · 2026Review
- The optical nose: Monolayer sensitization of Au surfaces for plasmonic gas sensing.Science advances · 2026Article
- Exhaled Volatile Organic Compounds in Ischemic Cardiomyocytes: Signatures of Oxidative Stress!Reviews in cardiovascular medicine · 2026Review
- Polycystic ovary syndrome (PCOS): current insights, emerging therapeutics, and future treatment strategies.Inflammopharmacology · 2026Review
- Metabolomic breath landscape analysis unravels lipid biomarker candidates in patients with genetic and idiopathic Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Breathomics in Diabetes Management: A Noninvasive Approach for Precision Health Monitoring.Journal of diabetes research · 2026Review
- The Potential of Exhaled Breath Analysis for Alzheimer's Disease Monitoring (mini review).Advances in experimental medicine and biology · 2026Review
- Breath by Breath: Navigating the Landscape of Exhaled Breath in Clinical Research and Prospects for the Future.Journal of analytical methods in chemistry · 2026Review
- Quantification of breath metabolites in labouring versus non-labouring patients: a feasibility study.British journal of anaesthesia · 2025Observational
- Exhaled Aldehydes and Ketones as Biomarkers of Lung Cancer and Diabetes: Review of Sensor Technologies for Early Disease Diagnosis.Biosensors · 2025Review
- Beyond Binary: A Machine Learning Framework for Interpreting Organismal Behavior in Cancer Diagnostics.Biomedicines · 2025Review
- Oral Microbiota Taxa and Pri-miRNA Expression in Bipolar Disorder: A Case-Control Study.Biomolecules · 2025Article
- Parallel Offline Breath Sampling for Cross-Validated Analysis of Volatile Organic Compound Metabolites.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Colorectal Cancer Detection Through Sweat Volatilome Using an Electronic Nose System and GC-MS Analysis.Cancers · 2025Article
- Exploring exhaled volatile organic compounds as potential biomarkers in anti-MDA5 antibody-positive interstitial lung disease.Molecular and cellular biochemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breath analysis is a relatively recent field of research with much promise in scientific and clinical studies. Breath contains endogenously produced volatile organic components (VOCs) resulting from metabolites of ingested precursors, gut and air-passage bacteria, environmental contacts, etc. Numerous recent studies have suggested changes in breath composition during the course of many diseases, and breath analysis may lead to the diagnosis of such diseases. Therefore, it is important to identify the disease-specific variations in the concentration of breath to diagnose the diseases. In this review, we explore methods that are used to detect VOCs in laboratory settings, VOC constituents in exhaled air and other body fluids (e.g., sweat, saliva, skin, urine, blood, fecal matter, vaginal secretions, etc.), VOC identification in various diseases, and recently developed electronic (E)-nose-based sensors to detect VOCs. Identifying such VOCs and applying them as disease-specific biomarkers to obtain accurate, reproducible, and fast disease diagnosis could serve as an alternative to traditional invasive diagnosis methods. However, the success of VOC-based identification of diseases is limited to laboratory settings. Large-scale clinical data are warranted for establishing the robustness of disease diagnosis. Also, to identify specific VOCs associated with illness states, extensive clinical trials must be performed using both analytical instruments and electronic noses equipped with stable and precise sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.