Evidence map›Paper›PMID 36728881›Full record

ArticleEuropean journal of gastroenterology & hepatology2023

Recurrence of hepatocellular carcinoma in noncirrhotic patients with nonalcoholic fatty liver disease versus hepatitis B infection.

Jungnam Lee, Jong-In Chang, Young-Joo Jin, Jeong-Hoon Lee, Ju Yeon Kim, Dong Hyun Sinn, Soon Sun Kim, Hyun Woong Lee, Sun Hong Yoo, Jung Hwan Yu and 1 more

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Article in European journal of gastroenterology & hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jungnam LeeDepartment of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon.
Jong-In ChangDepartment of Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong.
Young-Joo JinDepartment of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon.
Jeong-Hoon LeeDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul.
Ju Yeon KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul.
Dong Hyun SinnDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.
Soon Sun KimDepartment of Gastroenterology, Ajou University School of Medicine, Suwon.
Hyun Woong LeeDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul.
Sun Hong YooDepartment of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, South Korea.
Jung Hwan YuDepartment of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon.
Jin-Woo LeeDepartment of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThis study aimed to compare the long-term cumulative recurrence rates of hepatocellular carcinoma (HCC) and prognosis after curative resection for HCC in noncirrhotic patients with nonalcoholic fatty liver disease (NAFLD) versus hepatitis B virus (HBV) infection.

methodsWe retrospectively analyzed the data of 791 patients without recurrence within 1 year after curative resection for HCC from January 2005 to December 2015. Of these, 63 and 728 were NAFLD and HBV patients without cirrhosis, respectively.

resultsRecurrence of HCC was observed in 6 (9.5%) and 210 (28.8%) patients in the NAFLD and HBV groups, respectively, during median follow-ups of 69.9 and 85.2 months. Cumulative recurrence rates in the NAFLD group at 2, 4, 6, 8 and 10 years (3.6, 9.4, 12.4, 12.4 and 12.4%, respectively) were significantly lower than in the HBV group (1.7, 16.9, 27.2, 37.1 and 44.4%, respectively) ( P  = 0.008). Cumulative overall survival (OS) rates in the NAFLD group at 2, 4, 6, 8 and 10 years (98.2, 96.0, 84.0, 84.0 and 84.0 %, respectively) were significantly lower than in the HBV group (99.3, 98.4, 97.3, 95.7 and 93.6%, respectively) ( P  = 0.003). HBV infection, with or without fatty liver compared to NAFLD, were significant predictors for the recurrence of HCC ( P  < 0.05 for all) and OS ( P  < 0.05 for all), respectively.

conclusionsNoncirrhotic NAFLD patients showed lower recurrence rates of HCC but poorer survival outcomes than noncirrhotic HBV patients with or without fatty liver. The recurrence risk of HCC remains even in noncirrhotic NAFLD patients.

Indexed as

Carcinoma, HepatocellularHepatitis BLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseHepatitis B virusHumansNeoplasm Recurrence, LocalRetrospective Studies

Identifiers

PMID36728881

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