Evidence map›Paper›PMID 36728431›Full record

ArticlemBio2023

Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection.

Sandhya Ganesan, Natalie N Alvarez, Samuel Steiner, Karen M Fowler, Abigail K Corona, Craig R Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Review
  3. Article
  4. Identification of aInfection and immunity · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sandhya GanesanDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Natalie N AlvarezDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.
Samuel SteinerDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Karen M FowlerDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Abigail K CoronaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Craig R RoyDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-4490-440X
Yale University · USEmory University · US

Funding

Biogenesis of the Coxiella-containing vacuoleR01AI114760 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2015 to 2019
$2.1M
Modulation of Host Cell Functions by Coxiella burnetiiR01AI064559 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2006 to 2010
$1.8M
NIAID NIH HHS R01 AI064559NIAID NIH HHS R01 AI114760
6 · The paper itself

Abstract

There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of the lysosome. It has been shown that gamma interferon (IFNγ)-stimulated host cells restrict C. burnetii replication by a mechanism that involves host IDO1 depletion of tryptophan. Host cells deficient in IDO1 activity, however, retain the ability to restrict C. burnetii replication when stimulated with IFNγ, which suggests additional mechanisms of host defense. This study identified syntaxin 11 (STX11) as a host protein that contributes to IFNγ-mediated suppression of C. burnetii replication. STX11 is a SNARE protein; SNARE proteins are proteins that mediate fusion of host vesicles with specific subcellular organelles. Depletion of STX11 using either small interfering RNA (siRNA)- or CRISPR-based approaches enhanced C. burnetii replication intracellularly. Stable expression of STX11 reduced C. burnetii replication in epithelial cells and macrophages, which indicates that this STX11-dependent cell-autonomous response is operational in multiple cell types and can function independently of other IFNγ-induced factors. Fluorescently tagged STX11 localized to the

Indexed as

Coxiella burnetiiQ FeverHost-Pathogen InteractionsHumansInterferon-gammaInterferonsQa-SNARE ProteinsRNA, Small InterferingVacuolesInterferon-gammaInterferonsQa-SNARE ProteinsRNA, Small InterferingSTX11 protein, humanCoxiellainnate immunityinterferonsintracellular bacteriaphagosomessecretion systems

Identifiers

PMID36728431
PMCPMC9972978
OpenAlexW4318920755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.