Evidence map›Paper›PMID 36727672›Full record

ArticleMolecular oncology2023

Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma.

Mélody Caillot, Hadjer Miloudi, Antoine Taly, Nuria Profitós-Pelejà, Juliana C Santos, Marcelo L Ribeiro, Elsa Maitre, Simon Saule, Gaël Roué, Fabrice Jardin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Detection ofInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mélody CaillotNormandie Univ, INSERM, Unicaen, Caen, France.
Hadjer MiloudiNormandie Univ, INSERM, Unicaen, Caen, France.
Antoine TalyLaboratoire de Biochimie Théorique, CNRS, Université de Paris, Paris, France.
Nuria Profitós-PelejàLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain.
Juliana C SantosLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain.
Marcelo L RibeiroLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain.
Elsa MaitreNormandie Univ, INSERM, Unicaen, Caen, France.
Simon SauleInstitut Curie, PSL Research University, CNRS, INSERM, Orsay, France.
Gaël RouéLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain.ORCID 0000-0003-0245-2257
Fabrice JardinNormandie Univ, INSERM, Unirouen, Rouen, France.
Brigitte SolaNormandie Univ, INSERM, Unicaen, Caen, France.ORCID 0000-0001-7278-9651
Inserm · FRJosep Carreras Leukaemia Research Institute · ESCentre National de la Recherche Scientifique · FRUniversité Paris-Sud · FR

Funding

Cancéropôle Nord-OuestFondation d'Entreprise Grand-OuestLigue Contre le Cancer CD76Spanish Ministry of Economy and Competitiveness PID2021-123039OB-C21
6 · The paper itself

Abstract

Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to inhibit XPO1. In primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin's lymphoma (cHL), the XPO1 gene may be mutated on one nucleotide and encodes the mutant XPO1

Indexed as

Hodgkin DiseaseActive Transport, Cell NucleusCell Line, TumorCell NucleusCytoplasmExportin 1 ProteinHumansHydrazinesReceptors, Cytoplasmic and NuclearTriazolesExportin 1 ProteinHydrazinesReceptors, Cytoplasmic and NuclearselinexorTriazolesibrutinibimportazoleimportin β1NFκB signalingselinexor

Identifiers

PMID36727672
PMCPMC10701774
OpenAlexW4318932563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.