ArticleEpilepsia2023
A library of quantitative markers of seizure severity.
Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Markers of Antiseizure Treatment Efficacy in Children: A Review.Journal of clinical medicine · 2026Review
- Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain.Brain structure & function · 2025Article
- More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.Epilepsia · 2025Article
- Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo.Nature communications · 2024Article
- Generalisability of epileptiform patterns across time and patients.Scientific reports · 2024Article
- Diazepam nasal spray administration is effective to control seizure clusters irrespective of time of day.Frontiers in neurology · 2024Article
- The seizure severity score: a quantitative tool for comparing seizures and their response to therapy.Journal of neural engineering · 2023Article
- Temporal stability of intracranial electroencephalographic abnormality maps for localizing epileptogenic tissue.Epilepsia · 2023Article
- A library of quantitative markers of seizure severity.Epilepsia · 2023Article
- Chronic intracranial EEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states.Brain communications · 2023Article
- Ictal gamma increase shows preferential localization to seizure onset contacts in stereoelectroencephalography.Frontiers in neurologyArticle
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveUnderstanding fluctuations in seizure severity within individuals is important for determining treatment outcomes and responses to therapy, as well as assessing novel treatments for epilepsy. Current methods for grading seizure severity rely on qualitative interpretations from patients and clinicians. Quantitative measures of seizure severity would complement existing approaches to electroencephalographic (EEG) monitoring, outcome monitoring, and seizure prediction. Therefore, we developed a library of quantitative EEG markers that assess the spread and intensity of abnormal electrical activity during and after seizures.
methodsWe analyzed intracranial EEG (iEEG) recordings of 1009 seizures from 63 patients. For each seizure, we computed 16 markers of seizure severity that capture the signal magnitude, spread, duration, and postictal suppression of seizures.
resultsQuantitative EEG markers of seizure severity distinguished focal versus subclinical seizures across patients. In individual patients, 53% had a moderate to large difference (rank sum SIGNIFICANCE: We demonstrate the feasibility of using quantitative iEEG markers to measure seizure severity. Our quantitative markers distinguish between seizure types and are therefore sensitive to established qualitative differences in seizure severity. Our results also suggest that seizure severity is modulated over different timescales. We envisage that our proposed seizure severity library will be expanded and updated in collaboration with the epilepsy research community to include more measures and modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.