Evidence map›Paper›PMID 36727049›Full record

ReviewFrontiers in oncology2022

Exosomes and cancer immunotherapy: A review of recent cancer research.

Yue Cao, Peng Xu, Yangling Shen, Wei Wu, Min Chen, Fei Wang, Yuandong Zhu, Feng Yan, Weiying Gu, Yan Lin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  7. Integrating plasma exosomal miRNAs, ultrasound radiomics and tPSA for the diagnosis and prediction of early prostate cancer: a multi-center study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue CaoDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Peng XuDepartment of Hematology, Soochow Hopes Hematology Hospital, Suzhou, Jiangsu, China.
Yangling ShenDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Wei WuDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Min ChenDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Fei WangDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Yuandong ZhuDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Feng YanDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Weiying GuDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Yan LinDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy.

Indexed as

exosomeextracellular vesiclegastrointestinal cancerimmunotherapytumor immune microenvironment

Identifiers

PMID36727049
PMCPMC9885269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.