ArticleFrontiers in surgery2022
Atypical location of primary cardiac lymphoma in the left heart with atypical clinical presentation: A case report and literature review.
Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Clinicopathological analysis of 124 cardiac tumors: a single-center retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Considerations on the Diagnosis and Prognosis of Primary Cardiac Lymphoma.Arquivos brasileiros de cardiologia · 2026Article
- Rituximab-based regimens for primary cardiac lymphoma: A systematic review of outcomes, challenges and future directions.World journal of clinical oncology · 2025Article
- Case Report: A very rare case of diffuse large B-cell lymphoma with cardiac and ovarian involvement.Frontiers in oncology · 2025Article
- A rare case of primary cardiac diffuse large B-cell lymphoma imaged withFrontiers in medicine · 2024Article
- Diffuse Large B-Cell Lymphoma With Cardiac Invasion Presented as Acute Myocardial Infarction and Left Ventricular Hypertrophy: A Case Report.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
11 authors at 2 institutions in 2 countries.
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Abstract
Background: Primary cardiac lymphoma (PCL) is a rare and aggressive cardiac tumor with very poor prognosis that occurs mostly in the right cardiac cavity. Early diagnosis and treatment may improve its prognosis. In the present report, we describe the diagnosis and treatment of a primary cardiac diffuse large B-cell lymphoma (PC-DLBCL) with atypical location and clinical presentation. Additionally, a literature review was conducted to summarize the current knowledge of the disease. Case Presentation: A 71-year-old man visited his local hospital because of syncope, recurrent chest tightness, shortness of breath, palpitations, and profuse sweating for more than 20 days. Chest radiography revealed a mediastinal mass. Cardiac computed tomography (CT) showed multiple enlarged mediastinal lymph nodes. Transthoracic echocardiography (TTE) showed a cardiac mass in the posterior-inferior wall of the left atrium. He was then transferred to our hospital for positron emission tomography-CT (PET-CT) which showed active uptake of fluorodeoxyglucose both in the cardiac mass and in the multiple enlarged mediastinal lymph nodes. Biopsy of the enlarged mediastinal lymph nodes was carried out by using video-assisted thoracic surgery (VATS) technique, and pathological examination confirmed the subtype of PC-DLBCL, Stage IV, NCCN IPI 3. Therefore, the patient received a combination of chemotherapy and immunotherapy with R-CDOP (rituximab, cyclophosphamide, liposome doxorubicin, vincristine, and prednisone). After four courses of treatment in 4 months, the cardiac lymphoma and the enlarged mediastinal lymph nodes achieved complete remission with mild side effects of the chemotherapy. Conclusion: Early diagnosis and a precise choice of chemotherapy and immunotherapy based on cardiac imaging and pathological examination may improve the prognosis of PC-DLBCL in an atypical location.
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