SynthesisFrontiers in neurology2022
Anatomical variations in the Circle of Willis and the formation and rupture of intracranial aneurysms: A systematic review and meta-analysis.
Synthesis in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The anterior communicating artery variants: a meta-analysis with a proposed classification system.Surgical and radiologic anatomy : SRA · 2024Pooled it
- Rare circle of Willis variants associated with multiple intracranial aneurysms and subarachnoid hemorrhage: A case report.Medicine · 2026Article
- CFD-driven optimization and experimental validation of venturi-based thrombectomy devices in a circle of willis.Scientific reports · 2026Article
- Association between the A1 Segment Asymmetry and Severe Clinical Presentation in Ruptured Anterior Communicating Artery Aneurysms.Neurologia medico-chirurgica · 2026Article
- Atypical variants of the cerebral arterial circle beyond the Lazorthes classification: a retrospective morphologic and neuroradiologic study.Surgical and radiologic anatomy : SRA · 2026Article
- HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches.Inflammopharmacology · 2026Review
- Comparing Antemortem CT-Angiography Data with Autopsy Findings in Regard to Anterior Communicating Artery Aneurysms.NeuroSci · 2025Article
- Intracranial aneurysm location: potential influencing factor in ruptures with internal carotid artery occlusion.BMC neurology · 2025Article
- Sex-Specific Association between Anatomic Variants of the Circle of Willis and Intracranial Aneurysms in Individuals with a Familial Predisposition.AJNR. American journal of neuroradiology · 2025Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The anterior (AcomA) and posterior communicating arteries (PcomA) are two of the most frequent sites for intracranial aneurysms. Anatomical variations in the Circle of Willis (COW) are frequently observed in patients with AcomA and PcomA aneurysms. Strong evidence is needed to determine the pooled estimate of the effect of COW variations on the formation and rupture of these aneurysms. Aim: This systematic review and meta-analysis aimed to establish the effect of COW variations on the formation and rupture of AcomA and PcomA aneurysms using available studies. Summary of review: PubMed, Embase, and Web of Science databases were systematically searched for studies published in English before September 21, 2022. Studies investigating AcomA aneurysms and the hypoplastic/aplastic A1 segment of the anterior cerebral artery and PcomA aneurysms and hypoplastic/aplastic PcomA or fetal-type posterior cerebral artery (FTP) were included. The heterogeneity of the studies was assessed using Cochran Conclusions: Significant associations were observed between COW variations and both the formation and rupture of AcomA and PcomA aneurysms. This can help in determining interventions for patients with aneurysms. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=225149, identifier: CRD42021225149.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.