Evidence map›Paper›PMID 36726695›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2023

Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.

Sébastien Tanaka, Christian De Tymowski, Alexy Tran-Dinh, Olivier Meilhac, Brice Lortat-Jacob, Nathalie Zappella, Sylvain Jean-Baptiste, Tiphaine Robert, Tiphaine Goletto, Cendrine Godet and 7 more

Abstract read
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In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sébastien TanakaDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Christian De TymowskiDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Alexy Tran-DinhDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Olivier MeilhacFrench Institute of Health and Medical Research (INSERM), U1188 Diabetes Atherothrombosis Réunion Indian Ocean (DéTROI), CYROI Platform, Réunion Island University, Saint-Denis de La Réunion, France.
Brice Lortat-JacobDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Nathalie ZappellaDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Sylvain Jean-BaptisteDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Tiphaine RobertDepartment of Biochemistry, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Tiphaine GolettoDepartment of Pneumology and Lung Transplantation, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Cendrine GodetDepartment of Pneumology and Lung Transplantation, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Yves CastierUFR Paris Nord, Université Paris Cité, Paris, France.
Hervé MalUFR Paris Nord, Université Paris Cité, Paris, France.
Pierre MordantUFR Paris Nord, Université Paris Cité, Paris, France.
Enora AtchadeDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Jonathan MessikaUFR Paris Nord, Université Paris Cité, Paris, France.
Philippe MontraversDepartment of Anesthesiology and Critical Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), Bichat-Claude Bernard Hospital, Paris, France.
Bichat Lung Transplant Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12-1.62] mmol/L vs. HDL-C = 1.55 [1.22-1.97] mmol/L,

Indexed as

CholesterolLung TransplantationCholesterol, HDLHumansMultivariate AnalysisProspective StudiesCholesterolCholesterol, HDLHDL-cholesterollipoproteinlung transplantationmortalityoutcome

Identifiers

PMID36726695
PMCPMC9884674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.