ArticleFrontiers in cellular and infection microbiology2022
The association between diabetes status and latent-TB IGRA levels from a cross-sectional study in eastern China.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The impact of an oral glucose load on IFN-γ-release in persons infected with Mycobacterium tuberculosis.BMC infectious diseases · 2024Trial
- Factors associated with interferon-gamma release assay positivity in patients with psoriasis: a cross-sectional study.BMC infectious diseases · 2026Article
- Risk Factors for False-Negative T-SPOT.TB Results in Bacteriologically Confirmed Pulmonary Tuberculosis: A Retrospective Cohort Study of 4,931 Patients.Infection and drug resistance · 2026Article
- A QuantiFERONInfection and drug resistance · 2026Article
- Epidemiology of latent tuberculosis and associated risk factors in Al-Madinah, Saudi Arabia: A hospital-based cross-sectional study.Journal of Taibah University Medical Sciences · 2025Article
- The characteristics of latent tuberculosis infection and its influencing factors in hospitalized patients in Suzhou, Jiangsu, China.PloS one · 2025Article
- HIV and diabetes impairIJTLD open · 2024Article
- Comparative Evaluation of Diagnostic Performance: Standard E TB Feron ELISA vs QuantiFERON-TB Gold Plus for Latent Tuberculosis Infection Detection in Diverse Risk Groups in Bangladesh.Infection and drug resistance · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is a debate regarding the sensitivity of the QuantiFERON-TB Gold In-Tube (QFT) among people with diabetes, and prior studies have shown heterogeneous results. We evaluated whether the QFT TB antigen was modified among persons with differing diabetes status and other related risk factors. Methods: A cross-sectional study of 5,302 people was conducted to screen latent tuberculosis infection (LTBI) in eastern China. The QFT assay was performed as an indicator of LTBI. Fasting plasma glucose (FPG) was collected from each participant; the definition of diabetes followed the guidelines from the American Diabetes Association. Participants were classified into normoglycemia, prediabetes, undiagnosed diabetes, and previously diagnosed diabetes to evaluate the relationship between the QFT TB antigen and distinct diabetes status. Results: TB antigen values from the QFT were statistically different among participants with differing diabetes status ( Conclusions: Diabetes status had little influence on the level of QFT TB antigen response among IGRA-positive persons. However, FPG, old age, and smoking were important risk factors for increasing levels of QFT TB antigen.
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