Evidence map›Paper›PMID 36726610›Full record

ArticleRegenerative biomaterials2023

Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle.

Ellen Ngarande, Emma Doubell, Ousman Tamgue, Manuel Mano, Paul Human, Mauro Giacca, Neil Hamer Davies

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ellen NgarandeCardiovascular Research Unit, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.
Emma DoubellCardiovascular Research Unit, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.
Ousman TamgueInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Observatory 7925, South Africa.
Manuel ManoKing's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, WC2R 2LS, London, UK.
Paul HumanCardiovascular Research Unit, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.ORCID https://orcid.org/0000-0002-6007-5827
Mauro GiaccaKing's College London, British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, WC2R 2LS, London, UK.
Neil Hamer DaviesCardiovascular Research Unit, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.ORCID https://orcid.org/0000-0003-0432-4515
University of Cape Town · ZAKing's College London · GBSouth African Medical Research Council · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual tissues. Injectable hydrogels are one potentially simple and direct route towards overcoming these barriers. Here we report on the utility of a combination of a mildly modified form of the clinically utilised fibrin hydrogel with Invivofectamine

Indexed as

controlled releasefibrinlipopolyplexRNA interference

Identifiers

PMID36726610
PMCPMC9887344
OpenAlexW4311348866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.