ArticleRegenerative biomaterials2023
Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells.
Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biomimetic Core-Sheath GelMA/PCL Nanofibers for Enhanced Peripheral Nerve Regeneration.Polymers · 2026Article
- Form Meets Function: Fiber Architecture Directs Proliferation and Differentiation in Gingival Keratinocytes.Cells · 2026Article
- Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications.Regenerative biomaterials · 2026Review
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
- Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior.Advanced healthcare materials · 2025Review
- Electrospun Parallel, Crossed Fibers for Promoting Cell Adhesion and Migration.Materials (Basel, Switzerland) · 2025Article
- Modulating cell adhesion and infiltration in advanced scaffold designs based on PLLA fibers with rGO and MXene (TiMaterials today. Bio · 2025Article
- Surface modification of polyetheretherketone for boosted osseointegration: A review.Biomaterials translational · 2025Review
- Effects of protein conformational transition accompanied with crosslinking density cues in silk fibroin hydrogels on the proliferation and chondrogenesis of encapsulated stem cells.Regenerative biomaterials · 2025Article
- Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis.Frontiers in bioengineering and biotechnology · 2024Article
- Fibrous topology promoted pBMP2-activated matrix on titanium implants boost osseointegration.Regenerative biomaterials · 2024Article
- A facile nanopattern modification of silk fibroin electrospun scaffold and the corresponding impact on cell proliferation and osteogenesis.Regenerative biomaterials · 2024Article
- The Manufacturing Conditions for the Direct and Reproducible Formation of Electrospun PCL/Gelatine 3D Structures for Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2023Article
- A Dexamethasone-Loaded Polymeric Electrospun Construct as a Tubular Cardiovascular Implant.Polymers · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber features' effects on cell behaviors. Due to the inevitable 'interference' cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat. A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed herein. In this unique material platform, the 'interference' cell adhesions through interspace between fibers to the environment could be effectively ruled out by the non-fouling background. The 'interference' cell adhesions between adjacent fibers could also be excluded from the sparsely arranged (SA) fiber patterns. The influence of fiber diameter on stem cell behaviors is precisely and comprehensively investigated based on eliminating the undesired 'interference' cell adhesions in a controllable way. On the SA fiber patterns, small diameter fiber (SA-D1, D1 means 1 μm in diameter) may seriously restrict cell proliferation and osteogenesis when compared to the middle (SA-D8) and large (SA-D56) ones and SA-D8 shows the optimal osteogenesis enhancement effect. At the same time, the cells present similar proliferation ability and even the highest osteogenic ability on the densely arranged (DA) fiber patterns with small diameter fiber (DA-D1) when compared to the middle (DA-D8) and large (DA-D56) ones. The 'interference' cell adhesion between adjacent fibers under dense fiber arrangement may be the main reason for inducing these different cell behavior trends along with fiber diameters. Related results and comparisons have illustrated the effects of fiber diameter on stem cell behaviors more precisely and objectively, thus providing valuable reference and guidance for developing effective fibrous biomaterials.
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