Evidence map›Paper›PMID 36726391›Full record

ReviewTherapeutic advances in endocrinology and metabolism2023

MAFLD: a multisystem disease.

Rosaria Maria Pipitone, Carlo Ciccioli, Giuseppe Infantino, Claudia La Mantia, Stefanie Parisi, Adele Tulone, Grazia Pennisi, Stefania Grimaudo, Salvatore Petta

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 6 pooled it
41.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 6 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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  10. Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rosaria Maria PipitoneSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Carlo CiccioliSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Giuseppe InfantinoSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Claudia La MantiaSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Stefanie ParisiSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Adele TuloneSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Grazia PennisiSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Stefania GrimaudoSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Salvatore PettaSezione di Gastroenterologia e Epatologia, Di. Bi.M.I.S., Università di Palermo, Piazza delle Cliniche 2, Palermo 90127, Italy.ORCID https://orcid.org/0000-0002-0822-9673
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and its complications. Recently, an international consensus of experts proposed to rename this disease as 'Metabolic dysfunction-Associated Fatty Liver Disease' (MAFLD) to focus on the bidirectional interplay between fatty liver and metabolic alterations and to stress the need of assessing fatty liver independently from alcohol consumption and other coexisting causes of liver disease. The peculiarity of NAFLD/MAFLD lies in the presence of a higher risk of not only - as expected - liver-related events but also of extrahepatic events, mostly cardiovascular and cancers. Available evidence suggests that these associations are not only the expression of sharing the same risk factors but shed light about the ability of NAFLD/MAFLD and particularly of its progressive form - nonalcoholic/metabolic dysfunction-associated steatohepatitis - to act as an independent risk factor

Indexed as

fatty liverMAFLDNAFLD

Identifiers

PMID36726391
PMCPMC9885036
OpenAlexW4318922867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.