ArticleBMC ophthalmology2023
Proliferative diabetic retinopathy and diabetic macular edema are two factors that increase macrophage-like cell density characterized by en face optical coherence tomography.
Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Changes in the macrophage-like cells following progression and treatment of diabetic macular edema.Indian journal of ophthalmology · 2026Observational
- A Hierarchical Deep Learning Architecture for Diagnosing Retinal Diseases Using Cross-Modal OCT to Fundus Translation in the Lack of Paired Data.Journal of imaging · 2026Article
- Macrophage-Like Cell Density and Distribution in Relation to Vascular Leakage in Diabetes.Ophthalmology science · 2026Article
- Observational
- Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Inflammatory mechanisms in diabetic retinopathy: pathogenic roles and therapeutic perspectives.American journal of translational research · 2025Review
- Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease.The Journal of clinical investigation · 2024Article
- Vitreoretinal Interface Cells Correlate In Vivo With Uveitis Activity and Decrease With Anti-Inflammatory Treatment.Translational vision science & technology · 2024Article
- Quantifying Putative Retinal Gliosis in Preclinical Alzheimer's Disease.Investigative ophthalmology & visual science · 2024Article
- Macrophage activation contributes to diabetic retinopathy.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Association between macrophage-like cell density and ischemia metrics in diabetic eyes.Experimental eye research · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMacrophage-like cells (MLCs) located at the ILM were observed in live human retinas using adaptive optics optical coherence tomography (OCT) as well as clinically-used OCT. The study aimed to quantitatively analyzing MLCs at the vitreoretinal interface (VRI) in diabetic retinopathy (DR) using en face OCT and swept-source optical coherence tomography angiography (SS-OCTA).
methods190 DR eyes were included in the study, with 70 proliferative diabetic retinopathy (PDR) eyes and 120 non- proliferative diabetic retinopathy (NPDR) eyes. Sixty-three eyes from normal subjects were included as controls. MLCs were visualized in a 5 μm en face OCT slab above the VRI centered on the fovea. Mann-Whitney U test and Kruskal-Wallis H test were used to compare the OCTA parameters and the MLC parameters among groups. We evaluated the MLC density among groups on binarized images after image processing. We also investigated the relationship between MLC density and other OCT parameters including retina thickness and vessel density (VD).
resultsThe MLC density significantly increased in PDR eyes (PDR vs. NPDR, 8.97 (8.40) cells/mm
conclusionsSS-OCTA is a non-invasive and simple method for the characterization of MLCs at the VRI. PDR and DME are two factors that increase MLC density. MLC density also correlated with VD.
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