ArticleBMC pregnancy and childbirth2023
Perinatal characteristics and neonatal outcomes of singletons and twins in Chinese very preterm infants: a cohort study.
Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Early postnatal risk stratification for severe adverse outcomes in twin neonates admitted to the neonatal intensive care unit: development and temporal validation of an interpretable machine learning model.Translational pediatrics · 2026Article
- Determinants of growth parameters at 12-month corrected age among very preterm infants in China: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- In vitro Fertilisation and Prolonged Continuous Positive Airway Pressure are Associated with Treatment-Requiring Retinopathy of Prematurity in a Tertiary Referral Cohort: An Exploratory Clinical Epidemiology Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Observational
- Early childhood weight trajectory differences in twins, singletons, and gestational-age matched singletons.Preventive medicine reports · 2025Article
- Risk factors for neonatal admission from the beginning of pregnancy in Northeast Spain.Journal of paediatrics and child health · 2025Observational
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe prevalence of preterm birth has been rising, and there is a paucity of nationwide data on the perinatal characteristics and neonatal outcomes of twin deliveries of very preterm infants (VPIs) in China. This study compared the perinatal characteristics and outcomes of singletons and twins admitted to neonatal intensive care units (NICUs) in China.
methodsThe study population comprised all infants born before 32 weeks in the Chinese Neonatal Network (CHNN) between January 2019 and December 2019. Three-level and population-average generalized estimating equation (GEE)/alternating logistic regression (ALR) models were used to determine the association of twins with neonatal morbidities and the use of NICU resources.
resultsDuring the study period, there were 6634 (71.2%) singletons and 2680 (28.8%) twins, with mean birth weights of 1333.70 g and 1294.63 g, respectively. Twins were significantly more likely to be delivered by caesarean section (p < 0.01), have antenatal steroid usage (p = 0.048), have been conceived by assisted reproductive technology (ART) (p < 0.01), have a higher prevalence of maternal diabetes (p < 0.01) and be inborn (p < 0.01) than singletons. In addition, twins had a lower prevalence of small for gestational age, maternal hypertension, and primigravida mothers than singletons (all p < 0.01). After adjusting for potential confounders, twins had higher mortality rates (adjusted odds ratio [AOR] 1.28, 95% confidence interval [CI] 1.10-1.49), higher incidences of short-term composite outcomes (AOR 1.28, 95% CI 1.09-1.50), respiratory distress syndrome (RDS) (AOR 1.30, 95% CI 1.12-1.50), and bronchopulmonary dysplasia (BPD) (AOR 1.10, 95% CI 1.01-1.21), more surfactant usage (AOR 1.22, 95% CI 1.05-1.41) and prolonged hospital stays (adjusted mean ratio 1.03, 95% CI 1.00-1.06), compared to singletons.
conclusionOur work suggests that twins have a greater risk of mortality, a higher incidence of RDS and BPD, more surfactant usage, and longer NICU stays than singletons among VPIs in China.
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