ArticleNature2023
Single-cell spatial immune landscapes of primary and metastatic brain tumours.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 2 pooled it
104.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 2 syntheses or guidelines pooled it, 354 citations in OpenAlex.
- T cell immunity in glioma and potential implications for immunotherapy: A systematic review.Neuro-oncology · 2026Pooled it
- The Three Pillars of Glioblastoma: A Systematic Review and Novel Analysis of Multi-Omics and Clinical Data.Cells · 2024Pooled it
- A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis.Journal of neuro-oncology · 2025Trial
- L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial.Nature communications · 2024Trial
- Single-cell and intercellular communication analyses reveal DLL3 as a key regulator in the glioma tumor microenvironment.Molecular therapy. Nucleic acids · 2026Article
- Single-cell spatial immune landscape of ASFV-infected porcine lung microenvironment.Virulence · 2026Article
- Clinical metastatic cancer from initiation to colonization: emerging challenges and breakthroughs.Oncogene · 2026Review
- The emerging role of microbiota in neuro-oncology.Nature reviews. Neurology · 2026Review
- Glioma microenvironment: Cellular crosstalk, immunosuppression, and novel therapeutic perspectives.Chinese medical journal · 2026Review
- LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma.Journal for immunotherapy of cancer · 2026Article
- Accelerated immunostaining of thick biological tissues using bidirectional electric fields with reversible deformation.Biomedical optics express · 2026Article
- Targeting the miR-19b/PPP2R5E axis enhances temozolomide response in glioblastoma via ROS-induced DNA damage.British journal of cancer · 2026Article
- Spatial Omics in High-Grade Gliomas: Mapping Immune-Tumor Niches for Precision Therapy.Cancer medicine · 2026Review
- Chemotherapy-Activated GSK3β-DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatially resolved transcriptomics in human brain metastases identifies macrophage-tumor interactions associated with survival.iScience · 2026Article
- Spatial omics illuminates tumor heterogeneity.Cell reports methods · 2026Review
- IFI30 reprograms glioblastoma-associated macrophage and induces immune evasion by MAFF/PTGS2 pathway.Acta pharmaceutica Sinica. B · 2026Article
- Patient-derived resources for decoding and targeting brain metastases ecosystems.EMBO molecular medicine · 2026Review
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Review
192 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 3 countries.
Elham Karimi *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Miranda W Yu *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-3902-0124
Sarah M Maritan *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Lucas J M Perus *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Morteza RezanejadDepartments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada.
Mark SorinRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Matthew DanknerRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Parvaneh FallahGerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.
Samuel DoréRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Dongmei ZuoRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Benoit FisetRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-0372-8868
Daan J KloostermanDivision of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID 0000-0003-1082-070X
LeeAnn RamsayRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Yuhong WeiRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Stephanie LamDepartment of Diagnostic Radiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Roa AlsajjanDepartment of Medicine, Division of Neurology, King Saud University College of Medicine, Riyadh, Saudi Arabia.
Ian R WatsonRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-6025-3080
Gloria Roldan UrgoitiDepartment of Oncology, University of Calgary, Calgary, Alberta, Canada.
Morag ParkRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-5400-606X
Dieta BrandsmaDepartment of Neuro-Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
Donna L SengerGerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.
Jennifer A ChanArnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-9798-1551
Leila AkkariDivision of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID 0000-0001-5479-641X
Kevin PetreccaDepartment of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-8140-6402
Marie-Christine GuiotRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Peter M SiegelRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. peter.siegel@mcgill.ca.ORCID 0000-0002-5568-6586
Daniela F QuailRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.ORCID 0000-0002-6969-3250
Logan A WalshRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.ORCID 0000-0001-8771-2577
McGill University · CAThe Netherlands Cancer Institute · NLMontreal Neurological Institute and Hospital · CAUniversity of Calgary · CAJewish General Hospital · CAKing Saud University · SAMcGill Genome Centre · CAMcGill University Health Centre · CAUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell-cell relationships within the tumour microenvironment
Indexed as
Brain NeoplasmsGliomaSingle-Cell AnalysisTumor MicroenvironmentBrainDatasets as TopicGlioblastomaHumansMacrophagesNeoplasm MetastasisPeroxidaseMPO protein, humanPeroxidase
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.