ArticleNature2023
Single-cell spatial landscapes of the lung tumour immune microenvironment.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 2 pooled it
59.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
245 citing papers in PubMed, 2 syntheses or guidelines pooled it, 357 citations in OpenAlex.
- Deep learning in single-cell and spatial transcriptomics data analysis: advances and challenges from a data science perspective.Briefings in bioinformatics · 2025Pooled it
- Trends and hotspots in research related to tumor immune escape: bibliometric analysis and future perspectives.Frontiers in immunology · 2025Pooled it
- Artificial intelligence-powered spatial analysis of tumor microenvironment in patients with non-small cell lung cancer with acquired resistance to EGFR tyrosine kinase inhibitor.Journal for immunotherapy of cancer · 2025Trial
- Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial.Signal transduction and targeted therapy · 2024Trial
- The CRABP2-MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers.Molecular carcinogenesis · 2026Article
- A novel three-CpG signature for lung adenocarcinoma diagnosis: integrating multi-omics, machine learning, and clinical validation.Translational cancer research · 2026Article
- A Novel Prognostic Stratification for Patients with Non-small Cell Lung Cancer Following Surgical Resection After Neoadjuvant Therapy: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- SpaCEy links spatial tissue patterns to clinical outcomes using explainable graph neural networks.Nature communications · 2026Article
- Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC.Journal of translational medicine · 2026Article
- Article
- Clinical applications of artificial intelligence-driven nitric oxide: a bibliometric and scientific mapping analysis.Medical gas research · 2026Review
- Spatial omics illuminates tumor heterogeneity.Cell reports methods · 2026Review
- Loss of NCCRP1 overcomes immune evasion in lung adenocarcinoma.Journal for immunotherapy of cancer · 2026Article
- High-throughput microfluidics and machine learning-assisted screening of lipid nanoparticle formulations for siRNA delivery.Materials today. Bio · 2026Article
- Cellular architecture and neighborhood-informed virtual spatial tumor profiling from histopathology.Cell · 2026Article
- Spotlight on challenges and novel methods in highly multiplexed tissue imaging-based spatial proteomics.Journal of translational medicine · 2026Review
- Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases.Nature cancer · 2026Article
- Molecular and Immune Landscape of Recurrent and/or Distant Metastatic Squamous Cell Carcinoma of the Head and Neck: An EORTC/IMMUCAN Project.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review).Oncology reports · 2026Review
- Regulatory B-cell states in NSCLC immunotherapy resistance: mechanisms, spatial context and translational implications.Cancer immunology, immunotherapy : CII · 2026Review
185 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 1 country.
Mark Sorin *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Morteza Rezanejad *Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Elham Karimi *Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Benoit FisetRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-0372-8868
Lysanne DesharnaisRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Lucas J M PerusRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Simon MiletteRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Miranda W YuRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-3902-0124
Sarah M MaritanRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Samuel DoréRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Émilie PichetteFaculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
William EnlowInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada.ORCID 0000-0003-2990-9763
Andréanne GagnéInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada.ORCID 0000-0002-3833-4159
Yuhong WeiRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Michele OrainInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada.
Venkata S K ManemInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada.
Roni RayesRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Peter M SiegelRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-5568-6586
Sophie Camilleri-BroëtDepartment of Pathology, McGill University, Montreal, Quebec, Canada.
Pierre Olivier FisetDepartment of Pathology, McGill University, Montreal, Quebec, Canada.
Patrice DesmeulesInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada.
Jonathan D SpicerRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Daniela F QuailRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.ORCID 0000-0002-6969-3250
Philippe JoubertInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Quebec, Canada. philippe.joubert@criucpq.ulaval.ca.ORCID 0000-0001-7784-6387
Logan A WalshRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.ORCID 0000-0001-8771-2577
McGill University · CAInstitut universitaire de cardiologie et de pneumologie de Québec · CAMcGill University Health Centre · CAInnovation and Economic Development Trois Rivières · CAMcGill Genome Centre · CAUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-cell technologies have revealed the complexity of the tumour immune microenvironment with unparalleled resolution
Indexed as
Adenocarcinoma of LungLung NeoplasmsSingle-Cell AnalysisTumor MicroenvironmentCarcinoma, Non-Small-Cell LungDeep LearningDisease ProgressionHumansLungPrognosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.