ArticleMolecular psychiatry2023
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure.
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Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Components of event-related potentials and borderline personality disorder: a meta-analysis.European journal of psychotraumatology · 2023Pooled it
- Resting-State Neural Signatures of Moral Injury: Associations With Rumination.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.Journal of psychiatric research · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Racial Discrimination-Related Interoceptive Network Disruptions: A Pathway to Disconnection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Lifestyle and Transcriptional Signatures Associated with Ethnicity/Race-Related Variations in the Functional Connectome.Research (Washington, D.C.) · 2026Article
- Neural reactivity to a racial trauma cue in an African American woman with alcohol use disorder and PTSD: Case report.Psychiatry research case reports · 2025Article
- Leveraging biosensors in clinical and research settings: a guide to device selection.NPP - digital psychiatry and neuroscience · 2025Review
- Tempering an interpretation based on quality of data to make causal conclusions about race, inequities, and brain differences.Molecular psychiatry · 2025Article
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Conceptualizing disparities and differences in the psychobiology of traumatic stress.Journal of traumatic stress · 2024Review
- Population-level normative models reveal race- and socioeconomic-related variability in cortical thickness of threat neurocircuitry.Communications biology · 2024Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- The central executive network moderates the relationship between posttraumatic stress symptom severity and gastrointestinal related issues.Scientific reports · 2024Article
- Civilian Moral Injury and Amygdala Functional Connectivity During Attention to Threat.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol.BMC psychiatry · 2023Article
- Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.JAMA network open · 2023Article
- Differing associations of depersonalization with physiological response during rest and breath-focused mindfulness in a trauma-exposed female population.Journal of psychiatric research · 2023Article
- Brain morphological variability between whites and African Americans: the importance of racial identity in brain imaging research.Frontiers in integrative neuroscience · 2023Article
Corrections and comments
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Authors and funding
56 authors at 20 institutions in 2 countries.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA. nharnett@mclean.harvard.edu.ORCID 0000-0001-5346-2012
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7720-252X
Sierra CarterDepartment of Psychology, Georgia State University, Atlanta, GA, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Grace E RowlandDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
William M DavieDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Camilo GuzmanDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Lauren A M LeboisDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.ORCID 0000-0001-5816-9181
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-5690-5234
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-0160-7248
Antonia V SeligowskiDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
Sterling WintersDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Lana R GrasserDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-7168-5524
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-5693-190X
Mark J SeamonDepartment of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Xinming AnInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Donglin ZengDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1572-2626
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-5295-7072
Laura T GermineDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8690-8412
Kenneth A BollenDepartment of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Scott L RauchDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-7311-1121
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-2893-808X
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA.ORCID 0000-0001-8297-0024
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.ORCID 0000-0003-1939-3126
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0002-7546-1966
Robert A SworDepartment of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Jose L PascualPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erica HarrisEinstein Medical Center, Philadelphia, PA, USA.
Anna M ChangDepartment of Emergency Medicine, Jefferson University Hospitals, Philadelphia, PA, USA.ORCID 0000-0002-6494-9843
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Robert M DomeierDepartment of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, MI, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA.ORCID 0000-0002-5807-4382
Mark W MillerNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA.ORCID 0000-0001-6393-8563
Robert H PietrzakNational Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA.
Jutta JoormannDepartment of Psychology, Yale University, New Haven, CT, USA.
Deanna M BarchDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-1693-8506
Diego A PizzagalliDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-7772-1143
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
James M ElliottKolling Institute, University of Sydney, St Leonards, New South Wales, Australia.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4831-2305
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID 0000-0003-2978-7655
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-9482-3582
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-4674-0314
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-5158-1103
Harvard University · USEmory University · USUniversity of North Carolina at Chapel Hill · USWayne State University · USBrigham and Women's Hospital · USHenry Ford Health System · USUniversity of Florida · USUniversity of Pennsylvania · USWashington University in St. Louis · USYale University · USBaystate Medical Center · USBoston University · USBrown University · USCooper Medical School of Rowan University · USEinstein Medical Center Philadelphia · USGeorgia Institute of Technology · USGeorgia State University · USIndiana University School of MedicineJefferson University Hospitals · USMassachusetts General Hospital · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MLongitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8MThe University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)R33AG056540 · NIA · UNIVERSITY OF FLORIDA · PI ANTON, STEPHEN D · 2017 to 2021
$3.8MFacilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSDR01MH122867 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ANN M. RASMUSSON · 2020 to 2026
$3.6MImpact of Trauma Exposure on Critical Periods in Brain Development and Fear Processing in ChildrenR01MH111682 · NIMH · WAYNE STATE UNIVERSITY · PI JOVANOVIC, TANJA · 2016 to 2020
$3.0MBiological and Environmental Factors Affecting Risk and Resilience Among Syrian Refugee ChildrenR01HD099178 · NICHD · WAYNE STATE UNIVERSITY · PI JAVANBAKHT, ARASH · 2020 to 2024
$2.7MNeuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6MCharacterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679kA Multidimensional Neuroimaging Investigation of Posttraumatic Stress in HumansK00MH119603 · NIMH · MCLEAN HOSPITAL · PI HARNETT, NATHANIEL G · 2018 to 2021
$311kMRI and machine learning to improve early prognosis and clinical management after spinal cord injuryR03HD094577 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2019 to 2020
$195kNCATS NIH HHS UL1 TR001863NIA NIH HHS R33 AG056540NICHD NIH HHS R01 HD079076NICHD NIH HHS R01 HD099178NICHD NIH HHS R03 HD094577NIMH NIH HHS K00 MH119603NIMH NIH HHS K01 MH118467NIMH NIH HHS R01 MH111682NIMH NIH HHS R01 MH122867NIMH NIH HHS U01 MH110925
Abstract
Considerable racial/ethnic disparities persist in exposure to life stressors and socioeconomic resources that can directly affect threat neurocircuitry, particularly the amygdala, that partially mediates susceptibility to adverse posttraumatic outcomes. Limited work to date, however, has investigated potential racial/ethnic variability in amygdala reactivity or connectivity that may in turn be related to outcomes such as post-traumatic stress disorder (PTSD). Participants from the AURORA study (n = 283), a multisite longitudinal study of trauma outcomes, completed functional magnetic resonance imaging and psychophysiology within approximately two-weeks of trauma exposure. Seed-based amygdala connectivity and amygdala reactivity during passive viewing of fearful and neutral faces were assessed during fMRI. Physiological activity was assessed during Pavlovian threat conditioning. Participants also reported the severity of posttraumatic symptoms 3 and 6 months after trauma. Black individuals showed lower baseline skin conductance levels and startle compared to White individuals, but no differences were observed in physiological reactions to threat. Further, Hispanic and Black participants showed greater amygdala connectivity to regions including the dorsolateral prefrontal cortex (PFC), dorsal anterior cingulate cortex, insula, and cerebellum compared to White participants. No differences were observed in amygdala reactivity to threat. Amygdala connectivity was associated with 3-month PTSD symptoms, but the associations differed by racial/ethnic group and were partly driven by group differences in structural inequities. The present findings suggest variability in tonic neurophysiological arousal in the early aftermath of trauma between racial/ethnic groups, driven by structural inequality, impacts neural processes that mediate susceptibility to later PTSD symptoms.
Indexed as
FearStress Disorders, Post-TraumaticAmygdalaGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingPrefrontal Cortex
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