Evidence map›Paper›PMID 36725340›Full record

ArticleeNeuro2023

LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.

Bethany J Stieve, Madison M Smith, Esther Krook-Magnuson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bethany J StieveGraduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455 stiev009@umn.edu.ORCID 0000-0002-8030-6805
Madison M SmithDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455.
Esther Krook-MagnusonGraduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0002-6119-0165
University of Minnesota · US

Funding

Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
A novel inhibitory target for temporal lobe epilepsyR01NS104071 · NINDS · UNIVERSITY OF MINNESOTA · PI KROOK-MAGNUSON, ESTHER · 2018 to 2022
$1.6M
NINDS NIH HHS R01 NS104071NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) is notoriously pharmacoresistant, and identifying novel therapeutic targets for controlling seizures is crucial. Long-range inhibitory neuronal nitric oxide synthase-expressing cells (LINCs), a population of hippocampal neurons, were recently identified as a unique source of widespread inhibition in CA1, able to elicit both GABA

Indexed as

EpilepsyEpilepsy, Temporal LobeAnimalsDisease Models, AnimalFemalegamma-Aminobutyric AcidHippocampusKainic AcidMaleMiceSeizuresgamma-Aminobutyric AcidKainic Acidchannelrhodopsinclosed-loopGABAergicinterneuronnNOSresponsive neurostimulation

Identifiers

PMID36725340
PMCPMC9933934
OpenAlexW4318766054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.