Evidence map›Paper›PMID 36725311›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Engineered Sensory Nerve Guides Self-Adaptive Bone Healing via NGF-TrkA Signaling Pathway.

Zengjie Zhang, Fangqian Wang, Xin Huang, Hangxiang Sun, Jianxiang Xu, Hao Qu, Xiaobo Yan, Wei Shi, Wangsiyuan Teng, Xiaoqiang Jin and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 52 citations in OpenAlex.

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  5. [Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Zengjie ZhangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Fangqian WangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Xin HuangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Hangxiang SunDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Jianxiang XuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Hao QuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Xiaobo YanDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Wei ShiDepartment of Orthopedic, Taizhou First People's Hospital, Wenzhou Medical University, 218 Hengjie Road, Huangyan District, Taizhou City, Zhejiang Province, 318020, P. R. China.
Wangsiyuan TengDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Xiaoqiang JinDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Zhenxuan ShaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Yongxing ZhangDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Shenzhi ZhaoDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Yan WuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Zhaoming YeDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.
Xiaohua YuDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 88 Jiefang Road, Hangzhou City, Zhejiang Province, 310003, P. R. China.ORCID 0000-0002-0233-0121
Second Affiliated Hospital of Zhejiang University · CNWenzhou Medical University · CN

Funding

Medical and Key R&D Project of Zhejiang Province 2022C01076National Key Research and Development Projects 2018YFC1105400National Natural Science Foundation of China 31870959National Natural Science Foundation of China 81872173National Natural Science Foundation of China 82072959Natural Science Foundation of Zhejiang province GF22H068757Zhejiang Undergraduate Talent Project 2020R401218
6 · The paper itself

Abstract

The upstream role of sensory innervation during bone homeostasis is widely underestimated in bone repairing strategies. Herein, a neuromodulation approach is proposed to orchestrate bone defect healing by constructing engineered sensory nerves (eSN) in situ to leverage the adaptation feature of SN during tissue formation. NGF liberated from ECM-constructed eSN effectively promotes sensory neuron differentiation and enhances CGRP secretion, which lead to improved RAOECs mobility and osteogenic differentiation of BMSC. In turn, such eSN effectively drives ossification in vivo via NGF-TrkA signaling pathway, which substantially accelerates critical size bone defect healing. More importantly, eSN also adaptively suppresses excessive bone formation and promotes bone remodeling by activating osteoclasts via CGRP-dependent mechanism when combined with BMP-2 delivery, which ingeniously alleviates side effects of BMP-2. In sum, this eSN approach offers a valuable avenue to harness the adaptive role of neural system to optimize bone homeostasis under various clinical scenario.

Indexed as

OsteogenesisReceptor, trkACalcitonin Gene-Related PeptideNerve Growth FactorSignal TransductionCalcitonin Gene-Related PeptideNerve Growth FactorReceptor, trkABMP-2extracellular matrixnerve growth factorosteogenesissensory nerve

Identifiers

PMID36725311
PMCPMC10074090
OpenAlexW4318769609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.