ReviewJournal of the American College of Cardiology2023
Evolving Management Paradigm for Stable Ischemic Heart Disease Patients: JACC Review Topic of the Week.
Review in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial.The American journal of cardiology · 2024Trial
- Interaction between coronary lesion complexity and coronary microvascular dysfunction in the prognosis of NSTEMI patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- A Patient and Physician Perspective of Chronic Coronary Syndrome and Persistent Stable Angina in Brazil.Cardiology and therapy · 2026Review
- Article
- Drug-Coated Balloon Percutaneous Coronary Intervention in Diabetic and Non-Diabetic Patients: A Large All-Comers Cohort of Mid-Term Outcomes and Predictors of Adverse Events.Journal of clinical medicine · 2026Article
- Effect of smoking on the diagnostic performance of computational fluid dynamics-derived CT-derived fractional flow reserve: a cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Coronary stenosis assessment: AI-based CT quantification, visual analysis of invasive angiography, and quantitative coronary angiography.Insights into imaging · 2026Article
- Turkish Validity and Reliability Study of the Cardiac Self-Efficacy Questionnaire.Florence Nightingale journal of nursing · 2026Article
- Global trends in ischemic heart disease among older adults (> 60 Years): analysis of epidemiological patterns and disease burden from 1990 through 2021.Journal of cardiothoracic surgery · 2026Article
- Machine learning-selected inflammation biomarkers for stable coronary artery disease with intermediate coronary lesions: potential for long-term prognosis in a multicenter cohort study.Frontiers in physiology · 2026Article
- Therapeutic efficacy of combined esmolol and carvedilol treatment for myocardial ischemia in patients with coronary heart disease.American journal of translational research · 2026Article
- Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Article
- Refractory angina: mechanisms and stratified treatment in obstructive and non-obstructive chronic myocardial ischaemic syndromes.European heart journal · 2025Review
- Coronary microvascular disease in patients referred to coronary angiography following coronary computed tomography angiography.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Observational
- New avenues for the assessment of stable ischemic heart disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- Coronary microvascular dysfunction and its role in heart failure with preserved ejection fraction for future prevention and treatment.American journal of preventive cardiology · 2025Article
- Effectiveness and Tolerability of Trimetazidine 80 mg Once Daily in Patients with Chronic Coronary Syndrome in Brazil: The V-GOOD Observational Study.Cardiology and therapy · 2025Article
- Coronary computed tomography angiography in primary care patients with chest pain or dyspnea - a cross-sectional study.BMC primary care · 2025Article
- Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Management of stable coronary artery disease (CAD) has been based on the assumption that flow-limiting atherosclerotic obstructions are the proximate cause of angina and myocardial ischemia in most patients and represent an important target for revascularization. However, the role of revascularization in reducing long-term cardiac events in these patients has been limited mainly to those with left main disease, 3-vessel disease with diabetes, or decreased ejection fraction. Mounting evidence indicates that nonepicardial coronary causes of angina and ischemia, including coronary microvascular dysfunction, vasospastic disorders, and derangements of myocardial metabolism, are more prevalent than flow-limiting stenoses, raising concerns that many important causes other than epicardial CAD are neither considered nor probed diagnostically. There is a need for a more inclusive management paradigm that uncouples the singular association between epicardial CAD and revascularization and better aligns diagnostic approaches that tailor treatment to the underlying mechanisms and precipitants of angina and ischemia in contemporary clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.