Evidence map›Paper›PMID 36724527›Full record

ArticleBlood advances2023

Risk of COVID-19 infection in long-term survivors of blood or marrow transplantation: a BMTSS report.

Emily E Johnston, Qingrui Meng, Lindsey Hageman, Jessica Wu, Elizabeth Ross, Shawn Lim, Nora Balas, Alysia Bosworth, Hok Sreng Te, Liton Francisco and 7 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Emily E JohnstonInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-9126-2169
Qingrui MengInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Lindsey HagemanInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Jessica WuInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Elizabeth RossInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Shawn LimInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Nora BalasInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Alysia BosworthDepartment of Population Sciences, City of Hope, Duarte, CA.ORCID 0000-0002-0662-5699
Hok Sreng TeDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.
Liton FranciscoInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
Ravi BhatiaDivision of Hematology, Oncology and Bone Marrow Transplantation, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-5740-2316
Stephen J FormanDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
F Lennie WongDepartment of Population Sciences, City of Hope, Duarte, CA.
Saro H ArmenianDepartment of Population Sciences, City of Hope, Duarte, CA.ORCID 0000-0003-2604-8603
Daniel J WeisdorfDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-8078-8579
Wendy LandierInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-3319-5652
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7755-5683
University of Alabama at Birmingham · USCity of Hope · USUniversity of Minnesota · US

Funding

BMT Survivor Study-2 (BMTSS-2)U01CA213140 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATIA, SMITA · 2019 to 2023
$6.8M
BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDYR01CA078938 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI BHATIA, SMITA · 2000 to 2003
$1.6M
NCI NIH HHS R01 CA078938NCI NIH HHS U01 CA213140
6 · The paper itself

Abstract

There is limited information regarding COVID-19 in long-term blood or marrow transplant (BMT) survivors. We leveraged the BMT Survivor Study (BMTSS) to address this gap. BMTSS included patients who underwent BMT at 1 of 3 sites in the United States between 1974 and 2014 and survived ≥2 years after BMT. A sibling cohort serves as a non-BMT comparison group. Participants (2430 BMT survivors; 780 non-BMT participants) completed the BMTSS survey between October 2020 and November 2021 about COVID-19 testing, risk mitigation behaviors, morbidity, and health care use. Median age at BMT was 46 years (range, 0-78 years) and median follow-up since BMT was 14 years (6-46 years); 76% were non-Hispanic White, 54% had received allogeneic BMT. The risk of COVID-19 infection was comparable for BMT survivors vs non-BMT participants (15-month cumulative incidence, 6.5% vs 8.1%; adjusted odd ratio [aOR] = 0.93; 95% confidence interval [CI], 0.65-1.33; P = .68). Among survivors, being unemployed (aOR 1.90; 95% CI, 1.12-3.23; P = .02; reference: retired) increased the odds of infection; always wearing a mask in public was protective (aOR = 0.49; 95% CI, 0.31-0.77; P = .002; reference: not always masking). When compared with COVID-positive non-BMT participants, COVID-positive BMT survivors had higher odds of hospitalization (aOR = 2.23; 95% CI, 0.99-5.05; P = .05); however, the odds of emergency department visits were comparable (aOR = 1.60; 95% CI = 0.71-3.58; P = .25). COVID-19 infection status did not increase the odds of hospitalization among BMT survivors (aOR = 1.32; 95% CI = 0.89-1.95; P = .17) but did increase the odds of emergency department visits (aOR = 2.63; 95% CI, 1.74-3.98; P <.0001). These findings inform health care providers about the management of care for long-term BMT survivors during the ongoing pandemic.

Indexed as

COVID-19COVID-19 TestingBone MarrowBone Marrow TransplantationHumansSurvivors

Identifiers

PMID36724527
PMCPMC9906674
OpenAlexW4318762896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.