ArticleProceedings of the National Academy of Sciences of the United States of America2023
Curvature gradient drives polarized tissue flow in the
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- The role of geometry in morphogenesis.Development (Cambridge, England) · 2026Review
- Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation.Nature communications · 2026Article
- A model for boundary-driven tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
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- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Article
- The Geometric Basis of Epithelial Convergent Extension.bioRxiv : the preprint server for biology · 2024Article
- A Hierarchical Mechanotransduction System: From Macro to Micro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.bioRxiv : the preprint server for biology · 2024Article
- Mechanical regulation of substrate adhesion and de-adhesion drives a cell-contractile wave during Drosophila tissue morphogenesis.Developmental cell · 2024Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- A mechanochemical model recapitulates distinct vertebrate gastrulation modes.Science advances · 2023Article
- Article
- Curvature gradient drives polarized tissue flow in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications.Seminars in cell & developmental biologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices, which is caused by the activation of actomyosin contractility. This can lead to long-range flows due to tissue viscosity. However, in the absence of cell-intrinsic polarized forces or polarity in forces external to the tissue, these flows must be symmetric and centered around the region of contraction. Polarized tissue flows have been previously demonstrated to arise from the coupling of such contractile flows to points of increased friction or adhesion to external structures. However, we show with experiments and modeling that the onset of polarized tissue flow in early
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.