Evidence map›Paper›PMID 36724234›Full record

ArticleScience advances2023

The ion transporter Na

Irene Chernova, Wenzhi Song, Holly Steach, Omeed Hafez, Jafar Al Souz, Ping-Min Chen, Nisha Chandra, Lloyd Cantley, Margaret Veselits, Marcus R Clark and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Something old, something new: NaClinical kidney journal · 2023
    Article
  9. Mechanism of B cell survival in lupus nephritis.Nature reviews. Nephrology · 2023
    Article
  10. Mechanism of B cell survival in lupus nephritis.Nature reviews. Rheumatology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Irene ChernovaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3346-0559
Wenzhi SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Holly SteachDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0018-3129
Omeed HafezDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Jafar Al SouzDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2345-2803
Ping-Min ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6532-4549
Nisha ChandraDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9186-4714
Lloyd CantleyDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Margaret VeselitsSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8755-6260
Marcus R ClarkSection of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4747-0387
Joe CraftDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1368-6756
Yale University · USUniversity of Chicago · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8M
IMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4M
Pathogenesis of Lupus NephritisR01AI152443 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft · 2020 to 2026
$3.8M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016359NIAID NIH HHS R01 AI152443NIAMS NIH HHS R37 AR040072NIDDK NIH HHS P30 DK079310
6 · The paper itself

Abstract

The kidney is a comparatively hostile microenvironment characterized by highsodium concentrations; however, lymphocytes infiltrate and survive therein in autoimmune diseases such as lupus. The effects of sodium-lymphocyte interactions on tissue injury in autoimmune diseases and the mechanisms used by infiltrating lymphocytes to survive the highsodium environment of the kidney are not known. Here, we show that kidney-infiltrating B cells in lupus adapt to elevated sodium concentrations and that expression of sodium potassium adenosine triphosphatase (Na

Indexed as

B-LymphocytesKidneyLupus NephritisSodium-Potassium-Exchanging ATPaseCell SurvivalHumansSodiumSodiumSodium-Potassium-Exchanging ATPase

Identifiers

PMID36724234
PMCPMC9891690
OpenAlexW4318933575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.