ArticleScience advances2023
RNA binding protein DDX5 restricts RORγt
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- DDX5 (p68) and UbE2T as emerging superior cancer therapeutic targets: dual molecular glue target degradation by FL118 for conquering difficult-to-treat cancers.Journal of experimental & clinical cancer research : CR · 2026Review
- Inhibition of DDX5-Mediated G-Quadruplex Unwinding in the β-Catenin 5'-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury.Research (Washington, D.C.) · 2026Article
- Inflammation associated microglial expansion disrupts hippocampal glial network communication, driving postoperative neurocognitive impairment.Journal of neuroinflammation · 2025Article
- An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex.Scientific reports · 2025Article
- The Hypoxia-Retinoid Axis in Idiopathic Pulmonary Fibrosis: Multifaceted Etiology and Therapeutic Potential.International journal of molecular sciences · 2025Review
- What's in a name: the multifaceted function of DNA- and RNA-binding proteins in T cell responses.The FEBS journal · 2025Review
- DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells.Nature communications · 2024Article
- The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology.Cell communication and signaling : CCS · 2024Review
- DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.EMBO reports · 2024Article
- Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence.Journal of experimental & clinical cancer research : CR · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Shengyun MaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3368-9388
Qiyuan YangNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-6204-9094
Nicholas ChenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1919-9059
Anna ZhengDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8431-6584
Nazia AbbasiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7686-4847
Gaowei WangDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Parth R PatelDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-2248-7281
Benjamin S ChoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Brian A YeeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5615-8550
Lunfeng ZhangDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA.
Hiutung ChuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7489-0446
Sylvia M EvansDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0799-6037
Ye ZhengNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Wendy Jia Men HuangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7425-8280
University of California San Diego · USSalk Institute for Biological Studies · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MFunctional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4MA Comprehensive Functional Map of Human Protein-RNA InteractionsU41HG009889 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2018 to 2021
$9.4MTreg development and function controlled by cis-regulatory circuitsR01AI107027 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2014 to 2022
$5.0MThe role of BAF related complexes in regulatory T cell development and functionR01AI151123 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, ZHENG, YE · 2020 to 2024
$4.0MPost-translational modifications in RORgt-dependent immune cell functionsR01GM124494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUANG, WENDY JIA MEN · 2017 to 2021
$2.0MThe Microbiome Mediates Protections from Colitis Through Pathways Linked to IBDR00DK110534 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHU, HIUTUNG · 2018 to 2020
$744kIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kA novel role of hypusination in controlling regulatory T cell functionR21AI154919 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2021 to 2022
$523kDefine the role of REV-ERB in colonic RORgt+ regulatory T cellsR21AI178938 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2023 to 2024
$523kNCI NIH HHS P30 CA014195NCI NIH HHS P30 CA023100NHGRI NIH HHS R01 HG004659NHGRI NIH HHS U41 HG009889NIAID NIH HHS R01 AI107027NIAID NIH HHS R01 AI151123NIAID NIH HHS R21 AI154919NIAID NIH HHS R21 AI178938NIDDK NIH HHS R00 DK110534NIGMS NIH HHS R01 GM124494NIH HHS S10 OD026929
Abstract
Retinoid-related orphan receptor (RAR) gamma (RORγt)-expressing regulatory T cells (RORγt
Indexed as
Interleukin-10Nuclear Receptor Subfamily 1, Group F, Member 3AnimalsDEAD-box RNA HelicasesGene Expression RegulationHumansMiceProtein BindingRNA-Binding ProteinsTranscription FactorsDdx5 protein, humanDEAD-box RNA HelicasesInterleukin-10Nuclear Receptor Subfamily 1, Group F, Member 3RNA-Binding ProteinsTranscription Factors
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.