ArticleScience advances2023
SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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Who cites it
132 citing papers in PubMed.
- Advancing the Volumetric Analysis of Ultra-Low-Field Brain MRI Using Image-to-Image Translation.Magnetic resonance in medicine · 2026Article
- Low-field MRI for equitable epilepsy diagnosis in resource-limited settings.Nature reviews. Neurology · 2026Article
- Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Improving racial fairness in brain age models using style-transfer synthesis.bioRxiv : the preprint server for biology · 2026Article
- Voice perception reflects graded sensitivity to acoustic cues along the auditory hierarchy.Current biology : CB · 2026Article
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- Causal evidence from invasive recordings reveals distributed acoustic feature encoding underlying categorical voice perception.NeuroImage · 2026Article
- Distinct neural processes link speech planning and execution.Nature human behaviour · 2026Article
- MRI-based cortical morphometry in traumatic brain injury: a pilot longitudinal study.Neuroradiology · 2026Article
- Cross-disorder comparison of brain structures among 4836 individuals with mental disorders and controls utilizing danish population-based clinical MRI scans.Molecular psychiatry · 2026Article
- Structural brain correlates of alexithymia in MS: the impact of corpus callosum volume and lesion localization.Acta neurologica Belgica · 2026Article
- Portable Ultra-Low Field MRI Deep-Learning Algorithms for White Matter Lesion Segmentation Improve Accuracy and Reflect Clinical Disability in Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2026Article
- Brain Morphology in Subacute Spinal Cord Injury: Insights Into Functional Recovery Across Brain Networks.Brain and behavior · 2026Article
- Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Time to tap into clinical MRI for brain volumetry research?European radiology · 2026Article
- Deep learning-based synthetic brain MRI for the assessment of regional atrophy patterns in neurodegenerative diseases.European radiology · 2026Article
- Spatial-temporal recurrence patterns of grade 4 glioma using deep learning integrated multiparametric MRI and molecular pathology.NPJ precision oncology · 2026Article
- Harmonization in magnetic resonance imaging: A survey of acquisition, image-level, and feature-level methods.Medical image analysis · 2026Review
72 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
Every year, millions of brain magnetic resonance imaging (MRI) scans are acquired in hospitals across the world. These have the potential to revolutionize our understanding of many neurological diseases, but their morphometric analysis has not yet been possible due to their anisotropic resolution. We present an artificial intelligence technique, "SynthSR," that takes clinical brain MRI scans with any MR contrast (T1, T2, etc.), orientation (axial/coronal/sagittal), and resolution and turns them into high-resolution T1 scans that are usable by virtually all existing human neuroimaging tools. We present results on segmentation, registration, and atlasing of >10,000 scans of controls and patients with brain tumors, strokes, and Alzheimer's disease. SynthSR yields morphometric results that are very highly correlated with what one would have obtained with high-resolution T1 scans. SynthSR allows sample sizes that have the potential to overcome the power limitations of prospective research studies and shed new light on the healthy and diseased human brain.
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