ArticlePloS one2023
Social isolation is linked to classical risk factors of Alzheimer's disease-related dementias.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Loneliness as an Interface Between Alzheimer's Disease and Suicidal Behaviour: A Systematic Review, Meta-Analysis and Meta-Analytic Factor Analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Pooled it
- The long-term impact of adverse childhood experiences on episodic memory in mid- to late-life among US older adults.Aging & mental health · 2026Article
- Stress, stress systems, and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Therapeutic Landscape of Early Symptomatic Alzheimer's Disease Translated into Everyday Practice for Geriatric Providers.Clinical interventions in aging · 2026Review
- Social Isolation, Loneliness, and Cognitive Health.Clinics in geriatric medicine · 2025Review
- Longitudinal changes in brain asymmetry track lifestyle and disease.Nature communications · 2025Article
- Article
- Social determinants of health extraction from clinical notes across institutions using large language models.NPJ digital medicine · 2025Article
- A University's Role in Developing a Regional Network of Dementia Friendly Communities.International journal of environmental research and public health · 2025Article
- Social Frailty and Social Isolation in the Context of Dementia: A Simultaneous Concept Analysis.International journal of geriatric psychiatry · 2025Review
- Insulin-like Growth Factor 1 Impact on Alzheimer's Disease: Role in Inflammation, Stress, and Cognition.Current issues in molecular biology · 2025Review
- Excessive Alcohol Use as a Risk Factor for Alzheimer's Disease: Epidemiological and Preclinical Evidence.Advances in experimental medicine and biology · 2025Review
- Pain can't be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design.BMC medicine · 2024Article
- Recent Advances in Therapeutics for the Treatment of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2024Review
- Racial and ethnic disparities in social isolation and 11-year dementia risk among older adults in the United States.Epidemiology and psychiatric sciences · 2024Article
- Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Best of Two Worlds to Promote Healthy Cognitive Aging: Definition and Classification Approach of Hybrid Physical Training Interventions.JMIR aging · 2024Article
- The Association Between Social Isolation and Incident Dementia Among Older Adults: Evidence From National Health and Aging Trend Study.Innovation in aging · 2024Article
- Theater-based interventions as a means of reducing social isolation and loneliness, facilitating successful aging, and strengthening social cognition in older adults.Frontiers in psychology · 2024Article
- Thirty Risk Factors for Alzheimer's Disease Unified by a Common Neuroimmune-Neuroinflammation Mechanism.Brain sciences · 2023Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease and related dementias is a major public health burden-compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals' social capital and various indicators of Alzheimer's disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.