Evidence map›Paper›PMID 36724055›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

Age-related differences in resting-state functional connectivity from childhood to adolescence.

Ashley F P Sanders, Michael P Harms, Sridhar Kandala, Scott Marek, Leah H Somerville, Susan Y Bookheimer, Mirella Dapretto, Kathleen M Thomas, David C Van Essen, Essa Yacoub and 1 more

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ashley F P SandersDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-8834-5489
Michael P HarmsDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
Sridhar KandalaDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
Scott MarekDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63119, USA.
Leah H SomervilleDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Susan Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA.
Mirella DaprettoDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA.
Kathleen M ThomasInstitute of Child Development, University of Minnesota, Minneapolis, MN 55455, USA.
David C Van EssenDepartment of Neuroscience, Washington University School of Medicine, St Louis, MO 63110, USA.
Essa YacoubCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.

Funding

Mapping the Human Connectome During Typical DevelopmentU01MH109589 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA, BOOKHEIMER, SUSAN Y · 2016 to 2019
$17.1M
Connectome Coordination FacilityR24MH108315 · NIMH · WASHINGTON UNIVERSITY · PI MARCUS, DANIEL SCOTT, VAN ESSEN, DAVID C · 2015 to 2019
$5.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Connectome Coordination Facility IIR24MH122820 · NIMH · WASHINGTON UNIVERSITY · PI MARCUS, DANIEL SCOTT, VAN ESSEN, DAVID C · 2020 to 2023
$3.4M
A High Performance Research Image Repository (RIR) for the Washington University Center of High Performance Computing (CHPC)S10OD030477 · OD · WASHINGTON UNIVERSITY · PI MARCUS, DANIEL SCOTT · 2021 to 2021
$1.9M
Acquisition of a next-generation computing clusterS10OD025200 · OD · WASHINGTON UNIVERSITY · PI TOBIAS, MALCOLM · 2019 to 2019
$597k
NIH HHS S10 OD025200NIH HHS S10 OD030477NIMH NIH HHS R24 MH108315NIMH NIH HHS R24 MH122820NIMH NIH HHS T32 MH100019NIMH NIH HHS U01 MH109589
6 · The paper itself

Abstract

The human brain is active at rest, and spontaneous fluctuations in functional MRI BOLD signals reveal an intrinsic functional architecture. During childhood and adolescence, functional networks undergo varying patterns of maturation, and measures of functional connectivity within and between networks differ as a function of age. However, many aspects of these developmental patterns (e.g. trajectory shape and directionality) remain unresolved. In the present study, we characterised age-related differences in within- and between-network resting-state functional connectivity (rsFC) and integration (i.e. participation coefficient, PC) in a large cross-sectional sample of children and adolescents (n = 628) aged 8-21 years from the Lifespan Human Connectome Project in Development. We found evidence for both linear and non-linear differences in cortical, subcortical, and cerebellar rsFC, as well as integration, that varied by age. Additionally, we found that sex moderated the relationship between age and putamen integration where males displayed significant age-related increases in putamen PC compared with females. Taken together, these results provide evidence for complex, non-linear differences in some brain systems during development.

Indexed as

BrainConnectomeAdolescentChildCross-Sectional StudiesFemaleHumansLongevityMagnetic Resonance ImagingMaleNeural Pathwaysbrain developmentgeneralised additive modelsparticipation coefficientresting-state functional connectivitysex differences

Identifiers

PMID36724055
PMCPMC10233258

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.