Evidence map›Paper›PMID 36723859›Full record

ArticleEuropean journal of public health2023

HIV treatment, antiretroviral adherence and AIDS mortality in people who inject drugs: a scoping review.

Anneli Uusküla, Jonathan Feelemyer, Don C Des Jarlais

Open access · goldAbstract readScoping Review
In one paragraph

Article in European journal of public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Anneli UuskülaDepartment of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.ORCID 0000-0002-4036-3856
Jonathan FeelemyerCollege of Global Public Health, New York University, New York, NY, USA.
Don C Des JarlaisCollege of Global Public Health, New York University, New York, NY, USA.
New York University · USUniversity of Tartu · EE

Funding

Combined prevention to reduce initiation into injecting drug useDP1DA039542 · NIDA · NEW YORK UNIVERSITY · PI DES JARLAIS, DON C · 2015 to 2019
$4.1M
NIDA NIH HHS DP1 DA039542
6 · The paper itself

Abstract

backgroundPeople who inject drugs (PWID) are a key population for the prevention and care of HIV infection.

methodsThis scoping review covers recent (post-2010) systematic reviews on engagement of PWID in sequential stages of HIV care from uptake, to achieving viral suppression, and to avoiding AIDS-related mortality.

resultsWe found that data on engagement of PWID into antiretroviral therapy (ART) were particularly scarce, but generally indicated very low engagement in ART. Studies of adherence and achieving viral suppression showed varying results, with PWID sometimes doing as well as other patient groups. The severity of social, medical and psychiatric disability in this population poses significant treatment challenges and leads to a marked gap in AIDS mortality between PWID and other population groups.

conclusionsGiven the multi-level barriers, it will be difficult to reach current targets (UNAIDS fast-track targets of 95-95-95) for ART for PWID in many locations. We suggest giving priority to reducing the likelihood that HIV seropositive PWID will transmit HIV to others and reducing morbidity and mortality from HIV infection and from other comorbidities.

Indexed as

Acquired Immunodeficiency SyndromeDrug UsersHIV InfectionsSubstance Abuse, IntravenousAnti-Retroviral AgentsHumansAnti-Retroviral Agents

Identifiers

PMID36723859
PMCPMC10234656
OpenAlexW4318753885

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.