ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2023
Modeling of Ultrasound Stimulation of Adolescent Pancreas for Insulin Release Therapy.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Article
- [Research advances in neuromodulation techniques for blood glucose regulation and diabetes intervention].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesOur previous published studies have focused on safety and effectiveness of using therapeutic ultrasound (TUS) for treatment of type 2 diabetes mellitus (T2DM) in preclinical models. Here we present a set of simulation studies to explore potential ultrasound application schemes that would be feasible in a clinical setting.
methodsUsing the multiphysics modeling tool OnScale, we created two-dimensional (2D) models of the human abdomen from CT images captured from one normal weight adolescent patient, and one obese adolescent patient. Based on our previous studies, the frequency of our TUS was 1 MHz delivered from a planar unfocused transducer. We tested five different insonation angles, as well as four ultrasound intensities combined with four different duty factors and five durations of application to explore how these variables effect the peak pressure and temperature delivered to the pancreas as well as surrounding tissue in the model.
resultsWe determined that ultrasound applied directly from the anterior of the patient abdomen at 5 W/cm
conclusionsOur modeling work indicates that it may be feasible to non-invasively apply TUS in clinical treatment of T2DM.
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