Evidence map›Paper›PMID 36722978›Full record

ArticleInfection and immunity2023

Nonredundant Dimethyl Sulfoxide Reductases Influence Salmonella enterica Serotype Typhimurium Anaerobic Growth and Virulence.

E Cruz, A L Haeberle, T L Westerman, M E Durham, M M Suyemoto, L A Knodler, J R Elfenbein

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Infection strategies ofGut microbes reports · 2026
    Review
  5. Article
  6. Article
  7. Applied and environmental microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

E CruzDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
A L HaeberlePaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
T L WestermanDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
M E DurhamDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
M M SuyemotoDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
L A KnodlerPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-3028-2198
J R ElfenbeinDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4764-0713
University of Wisconsin–Madison · USNorth Carolina State University · USWashington State University · US

Funding

An Interdisciplinary Training Program to Transform Graduate Education In Genetics and GenomicsT32GM140936 · NIGMS · UNIVERSITY OF MINNESOTA · PI ALBERT, FRANK WOLFGANG, GREENSTEIN, DAVID IRWIN · 2021 to 2025
$851k
Functional dissection of the retron St-85 of Salmonella TyphimuriumK08AI108794 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ELFENBEIN, JOHANNA REBECCA · 2014 to 2017
$602k
NIAID NIH HHS K08 AI108794NIGMS NIH HHS T32 GM140936
6 · The paper itself

Abstract

Facultative anaerobic enteric pathogens can utilize a diverse array of alternate electron acceptors to support anaerobic metabolism and thrive in the hypoxic conditions within the mammalian gut. Dimethyl sulfoxide (DMSO) is produced by methionine catabolism and can act as an alternate electron acceptor to support anaerobic respiration. The DMSO reductase complex consists of three subunits, DmsA, DmsB, and DmsC, and allows bacteria to grow anaerobically with DMSO as an electron acceptor. The genomes of nontyphoidal Salmonella enterica encode three putative

Indexed as

Dimethyl SulfoxideType III Secretion SystemsAnaerobiosisAnimalsIron-Sulfur ProteinsMammalsOxidoreductasesSalmonella typhimuriumSerogroupVirulenceDimethyl Sulfoxidedimethyl sulfoxide reductaseIron-Sulfur ProteinsOxidoreductasesType III Secretion Systemsanaerobic metabolismbovine ileal loop modeldimethyl sulfoxideDMSOmurine infectionSalmonellatype 3 secretion system

Identifiers

PMID36722978
PMCPMC9933680
OpenAlexW4318755800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.