Evidence map›Paper›PMID 36722949›Full record

ArticlemBio2023

Growth Arrest of Staphylococcus aureus Induces Daptomycin Tolerance via Cell Wall Remodelling.

Elizabeth V K Ledger, Andrew M Edwards

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolic reprogramming promotesMicrobiology (Reading, England) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth V K LedgerMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.ORCID 0000-0003-1126-6640
Andrew M EdwardsMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.ORCID 0000-0002-7173-7355
Imperial College London · GB

Funding

Department of HealthNIAID NIH HHS HHSN272200700055CWellcome TrustWellcome Trust 203812/Z/16/Z
6 · The paper itself

Abstract

Almost all bactericidal drugs require bacterial replication and/or metabolic activity for their killing activity. When these processes are inhibited by bacteriostatic antibiotics, bacterial killing is significantly reduced. One notable exception is the lipopeptide antibiotic daptomycin, which has been reported to efficiently kill growth-arrested bacteria. However, these studies employed only short periods of growth arrest (<1 h), which may not fully represent the duration of growth arrest that can occur

Indexed as

DaptomycinStaphylococcal InfectionsAnti-Bacterial AgentsBacteriaCell WallHumansMicrobial Sensitivity TestsPeptidoglycanStaphylococcus aureusAnti-Bacterial AgentsDaptomycinPeptidoglycanantibiotic tolerancedaptomycingrowth arrestMRSApeptidoglycanStaphylococcus aureus

Identifiers

PMID36722949
PMCPMC9973334
OpenAlexW4318753889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.