SynthesisBalkan medical journal2023
Effect of the Obesity Paradox on Mortality in Patients with Acute Coronary Syndrome: A Comprehensive Meta-analysis of the Literature
Synthesis in Balkan medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association of adipokines with major adverse cardiovascular events following acute myocardial infarction: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Evaluation of sleep quality and obstructive sleep apnea in non-alcoholic fatty liver disease: a cross-sectional study.BMC gastroenterology · 2026Article
- Studies on obesity-related atrial fibrillation in the past 20 years: A bibliometric analysis via CiteSpace and VOSviewer.Medicine · 2026Article
- Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review).International journal of molecular medicine · 2026Review
- Paradox of hepatitis B: Metabolic risk and cardiovascular protection in a national cohort.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Article
- Impact of MetS on Long-Term Prognosis Among STEMI Patients Treated with pPCI-Ten-Year Follow-Up Study.Medical sciences (Basel, Switzerland) · 2026Article
- Observational
- Impact of metabolically healthy and metabolically unhealthy obesity on cardiac arrest and mortality in pulmonary embolism hospitalizations in elderly patients with cancer.Lung India : official organ of Indian Chest Society · 2026Article
- Role of obesity and estrogen deficiency in non‑alcoholic fatty liver disease: Insights from a mouse model.Molecular medicine reports · 2025Article
- Association of anthropometric and obesity indices with abnormal blood lipid levels in young and middle-aged adults.Heliyon · 2025Article
- Bodyweight affects mortality in an L-shape pattern in patients undergoing coronary bypass grafting.Future cardiology · 2025Article
- Association of combined body mass index and central obesity with cardiovascular disease in middle-aged and older adults: a population-based prospective cohort study.BMC cardiovascular disorders · 2024Article
- The Effect of Obesity on Repolarization and Other ECG Parameters.Journal of clinical medicine · 2024Article
- Association of Body Mass Index with Outcomes in Patients with Atrial Fibrillation: Analysis from the (JoFib) Registry.Vascular health and risk management · 2024Article
- A synergistic impact of body mass index and gamma gap on heart failure and mortality rate among older patients with coronary artery disease: a prospective study with 10-year follow-up.Nutrition & diabetes · 2023Article
- Cardiovascular protective effect of sodium-glucose cotransporter 2 inhibitors on patients with acute coronary syndrome and type 2 diabetes mellitus: a retrospective study.BMC cardiovascular disorders · 2023Article
- Depression Following Acute Coronary Syndrome: A Review.Reviews in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The protective effect of obesity in patients with acute coronary syndrome undergoing percutaneous coronary intervention or bypass surgery has been described as the obesity paradox in the literature. Aims: In this comprehensive meta-analysis, we aimed to investigate the pooled effect of the obesity paradox on mortality in acute coronary syndrome patients. Study Design: Systemic meta-analysis and metaregression. Methods: We searched PubMed, Google Scholar, and the Cochrane Library for eligible studies that compared the mortality rates between body mass index cut-off points in acute coronary syndrome patients. This meta-analysis comprised 54 studies with 534,903 patients. Random- and fixed-effect models were used to calculate pooled effects sizes in the presence of moderately high and low heterogeneity between studies, respectively. A metaregression analysis was used to detect possible causes of heterogeneity. A dose-response meta-analysis was also conducted to detect the association between mortality risk and body mass index. Results: Overweight patients had lower mortality risk for 30-day (RR =0.69; 0.62-0.76, Conclusion: Low-weight and overweight acute coronary syndrome patients had higher mortality risk than normal-weight patients. A U-shaped nonlinear association was detected between body mass index and mortality risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.