GuidelineEndocrine, metabolic & immune disorders drug targets2023
Italian Guidelines for the Management of Non-Functioning Benign and Locally Symptomatic Thyroid Nodules.
Guideline in Endocrine, metabolic & immune disorders drug targets, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Cost-Effectiveness of Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: A Systematic Review.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Pooled it
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- 2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.European thyroid journal · 2023Guideline
- New gadgets for thyroid ablation-what's the promise?Gland surgery · 2026Article
- Patient-Reported Symptom Relief from Percutaneous Benign Thyroid Nodule Radiofrequency Ablation in Routine Clinical Care.AJNR. American journal of neuroradiology · 2026Article
- The correlation between the ultrasound examination parameters and the pathological characteristics of papillary thyroid carcinomas.Pakistan journal of medical sciences · 2025Article
- Review
- Incomplete ablation of thyroid cancer: Achilles' Heel?BMC endocrine disorders · 2024Article
- Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach.Cancers · 2024Review
- Article
- Article
- A novel guided approach to radiofrequency ablation of thyroid nodules: the Toronto Sunnybrook experience.Frontiers in endocrinology · 2024Article
- Response to the letter to the editor: Thyroid surgery volume - A statement issued by the Brazilian Head and Neck Surgery Society (SBCCP).Archives of endocrinology and metabolism · 2024Article
- Laser Ablation for Benign and Malignant Thyroid Nodules - A Mini-Literature Review.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Intraoperative frozen section for determining the extent of surgery in papillary thyroid carcinoma: comprehensive risk factor assessment.Gland surgery · 2023Article
- Factors Influencing a Favorable Outcome for RFA of Huge Benign Thyroid Nodules: Preliminary Results and Short-Term Evaluation.International journal of endocrinology · 2023Article
Corrections and comments
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Authors and funding
37 authors at 19 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis guideline (GL) is aimed at providing a reference for the management of non-functioning, benign thyroid nodules causing local symptoms in adults outside of pregnancy.
methodsThis GL has been developed following the methods described in the Manual of the National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices. Only outcomes classified as "critical" and "important" were considered in the systematic review of evidence and only those classified as "critical" were considered in the formulation of recommendations.
resultsThe present GL contains recommendations about the respective roles of surgery and minimally invasive treatments for the management of benign symptomatic thyroid nodules. We suggest hemithyroidectomy plus isthmectomy as the first-choice surgical treatment, provided that clinically significant disease is not present in the contralateral thyroid lobe. Total thyroidectomy should be considered for patients with clinically significant disease in the contralateral thyroid lobe. We suggest considering thermo-ablation as an alternative option to surgery for patients with a symptomatic, solid, benign, single, or dominant thyroid nodule. These recommendations apply to outpatients, either in primary care or when referred to specialists.
conclusionThe present GL is directed to endocrinologists, surgeons, and interventional radiologists working in hospitals, in territorial services, or private practice, general practitioners, and patients. The available data suggest that the implementation of this GL recommendations will result in the progressive reduction of surgical procedures for benign thyroid nodular disease, with a decreased number of admissions to surgical departments for non-malignant conditions and more rapid access to patients with thyroid cancer. Importantly, a reduction of indirect costs due to long-term replacement therapy and the management of surgical complications may also be speculated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.