ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023
Epidemiology of Invasive Nontypeable Haemophilus influenzae Disease-United States, 2008-2019.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Clinical Characteristics and Molecular Epidemiology of Invasive NontypeableOpen forum infectious diseases · 2026Article
- Live nontypeable Haemophilus influenzae exacerbates respiratory syncytial virus-associated lower airway inflammation.Respiratory research · 2026Article
- Review
- Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018-2023.Infectious diseases and therapy · 2026Article
- Chorioamnionitis in the Second Trimester Secondary to Multidrug-ResistantCase reports in infectious diseases · 2026Article
- Whole-genome and pan-genome analyses reveal genomic differences among nontypeableFrontiers in cellular and infection microbiology · 2026Article
- Clinical Course and Outcomes of Invasive Haemophilus influenzae Infections among Children at Two Hospitals in Alaska.The Journal of pediatrics · 2026Article
- Haemophilus influenzae Bacteremia With Polyarthritis and Uterine Fibroids in a 31-Year-Old Woman: A Case Report.Cureus · 2026Article
- Molecular detection ofNew microbes and new infections · 2025Article
- A Case of Lumbar Spinal Epidural Abscess and Facet Joint Septic Arthritis Caused byJournal of clinical medicine · 2025Article
- AASM case reports · 2025Article
- Intra-host genomic variation of serologically nontypeableMicrobiology spectrum · 2025Article
- Inflammatory Responses to Non-TypeablePathogens (Basel, Switzerland) · 2025Article
- Optimizing synthetic cystic fibrosis sputum media for growth of non-typeable Haemophilus influenzae.Access microbiology · 2025Article
- A Rare Presentation of Invasive NontypeableCase reports in infectious diseases · 2025Article
- Optimizing recovery of Haemophilus influenzae from vaginal-rectal specimens and determining carriage rates in pregnant women.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Changing Landscape ofCase reports in infectious diseases · 2024Article
- Genome Characterisation of InvasivePathogens (Basel, Switzerland) · 2023Article
- Vaginal carriage of Haemophilus influenzae in a non-pregnant reproductive-age population.BMC microbiology · 2023Article
- Epidemic Trends and Biofilm Formation Mechanisms of Haemophilus influenzae: Insights into Clinical Implications and Prevention Strategies.Infection and drug resistance · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundNontypeable Haemophilus influenzae (NTHi) is the most common cause of invasive H. influenzae disease in the United States (US). We evaluated the epidemiology of invasive NTHi disease in the US, including among pregnant women, infants, and people with human immunodeficiency virus (PWH).
methodsWe used data from population- and laboratory-based surveillance for invasive H. influenzae disease conducted in 10 sites to estimate national incidence of NTHi, and to describe epidemiology in women of childbearing age, infants aged ≤30 days (neonates), and PWH living in the surveillance catchment areas. H. influenzae isolates were sent to the Centers for Disease Control and Prevention for species confirmation, serotyping, and whole genome sequencing of select isolates.
resultsDuring 2008-2019, average annual NTHi incidence in the US was 1.3/100 000 population overall, 5.8/100 000 among children aged <1 year, and 10.2/100 000 among adults aged ≥80 years. Among 225 reported neonates with NTHi, 92% had a positive culture within the first week of life and 72% were preterm. NTHi risk was 23 times higher among preterm compared to term neonates, and 5.6 times higher in pregnant/postpartum compared to nonpregnant women. More than half of pregnant women with invasive NTHi had loss of pregnancy postinfection. Incidence among PWH aged ≥13 years was 9.5 cases per 100 000, compared to 1.1 cases per 100 000 for non-PWH (rate ratio, 8.3 [95% confidence interval, 7.1-9.7]; P < .0001).
conclusionsNTHi causes substantial invasive disease, especially among older adults, pregnant/postpartum women, and neonates. Enhanced surveillance and evaluation of targeted interventions to prevent perinatal NTHi infections may be warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.