Evidence map›Paper›PMID 36721715›Full record

ArticleGeneral psychiatry2023

Common susceptibility variants of

Yingying Yue, Linlin You, Fuying Zhao, Kezhong Zhang, Yanyan Shi, Hua Tang, Jianxin Lu, Shenghua Li, Jinxia Cao, Deqin Geng and 2 more

Open access · diamondAbstract read
In one paragraph

Article in General psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Issues and Solutions in Psychiatric Clinical Trial with Case Studies.Neuropsychiatric disease and treatment · 2024
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Yingying YueDepartment of Psychosomatics and Psychiatry, ZhongDa Hospital, Southeast University, Nanjing, China.
Linlin YouDepartment of Psychosomatics and Psychiatry, ZhongDa Hospital, Southeast University, Nanjing, China.
Fuying ZhaoDepartment of Psychiatry, Suzhou High-Tech Development District Yangshan Community Hospital, Suzhou, China.
Kezhong ZhangDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yanyan ShiDepartment of Neurology, Nanjing First Hospital, Nangjing, China.
Hua TangDepartment of Neurology, The Third People's Hospital of Huai'an, Huai'an, China.
Jianxin LuDepartment of Neurology, People's Hospital of Gaochun County, Nanjing, China.
Shenghua LiDepartment of Neurology, The Affiliated Nanjing Jiangning Hospital of Nanjing Medical Hospital, Nanjing, China.
Jinxia CaoDepartment of Neurology, The Second People's Hospital of Lianyungang, Lianyungang, China.
Deqin GengDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Aiqin WuDepartment of Psychosomatics, The Affiliated First Hospital of Soochow University, Soochow, China.
Yonggui YuanDepartment of Psychosomatics and Psychiatry, ZhongDa Hospital, Southeast University, Nanjing, China.ORCID 0000-0001-6496-3998
Zhongda Hospital Southeast University · CNXuzhou Medical College · CNCommunity Hospital · USGaochun People's Hospital · CNJiangsu Province Hospital · CNNanjing Jiangning Hospital · CNSoochow University · CNThe First People’s Hospital of Lianyungang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Depression, one of the most frequent complications after stroke, increases the disease's burden and physical disability. Poststroke depression (PSD) is a multifactorial disease with genetic, environmental and biological factors involved in its occurrence. Genetic studies on PSD to date have mainly focused on the monoamine system and brain-derived neurotrophic factors. However, understanding is still limited about the influence of the single nucleotide polymorphism (SNP) of other neurotrophic factors on PSD. Aims: The present study aimed to investigate the relationship between seven vascular endothelial growth factor (VEGF) family gene variants that occur with PSD. Methods: A multicentre candidate gene study from five hospitals in Jiangsu Province from June 2013 to December 2014 involved 121 patients with PSD and 131 patients with non-PSD. Demographic characteristics and neuropsychological assessments were collected. The χ Results: Patients with PSD included more women and those with lower education levels, lower body mass indexes, lower Mini-Mental State Examination scores, and higher scores on the 17-item Hamilton Depression Rating Scale than non-PSD patients. Ninety-two SNPs with seven genes were genotyped and passed quality control. The rs7692791 CC genotypes, the C allele of Conclusions: Patients with rs7692791 C allele carriers or the CC genotype of Trial registration number: ChiCTR-OCH-13003133.

Indexed as

Depression

Identifiers

PMID36721715
PMCPMC9827236
OpenAlexW4313646045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.