ArticleDrug design, development and therapy2023
Menthone Exerts its Antimicrobial Activity Against Methicillin Resistant
Article in Drug design, development and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- The efflux pump QacA mediates the transition to vancomycin heteroresistance in sequence type 5 methicillin-resistantEmerging microbes & infections · 2026Article
- Biological activities (antimicrobial, anti-inflammatory, anti-coronavirus (229E)) and chemical composition of some essential oils.Scientific reports · 2026Article
- Antioxidant, Photoprotective, and Antimicrobial Potential of Oil Extract ofMolecules (Basel, Switzerland) · 2026Article
- Electrospinning of Natural Polymeric Fibers with Essential Oils for the Control of Multidrug-Resistant Pathogens.Polymers · 2026Review
- Lipidome Disturbances ofMicroorganisms · 2026Article
- Anticancer and antioxidant activities of Pelargonium graveolens L., Mentha longifolia L., and Chrysanthemum frutescens L. under salt stress.Scientific reports · 2026Article
- Article
- Topical Formulations Containing Mentha piperita for Wound Healing: A Scoping Review.Chemistry & biodiversity · 2026Review
- Synergistic Effects of Plant Essential Oils and Extracts on Gut Microbiota in Rats.Foods (Basel, Switzerland) · 2026Article
- Chemical Composition, Biological Activity, and In VivoToxicity of Essential Oils Extracted from Mixtures of Plants and Spices.Molecules (Basel, Switzerland) · 2025Article
- Dual Mechanisms of Action of a Halogenated Allyl Fatty Acid against Methicillin-ResistantACS omega · 2025Article
- Potential of Essential Oils from Different Mint Species Against Multidrug-ResistantInternational journal of molecular sciences · 2025Article
- Volatile Compounds as Upcoming Antigiardial Agents: In Vitro Action of Carvacrol, Thymol and p-Cymene onPharmaceutics · 2025Article
- Integrated Phenotypic and Transcriptomic Analyses Unveil the Antibacterial Mechanism of Punicalagin Against Methicillin-ResistantFoods (Basel, Switzerland) · 2025Article
- Expediting multiple biological properties of main bioactive compounds of Mentha pulegium L.AMB Express · 2025Article
- Chemical Compositions and Antibacterial Activities ofJournal of agricultural and food chemistry · 2025Article
- A green approach to tangerine preservation: composite electro-blown nanofibers activated with cedarwood oil.Food science and biotechnology · 2025Article
- Thermally-triggered L-menthol release system based on starch sodium octenyl succinate/Nisin-stabilized high internal phase Pickering Emulsion: Development, characterization and meatball coating application.Current research in food science · 2025Article
- Menthone lowers H3K27ac levels to inhibitFrontiers in microbiology · 2025Article
- Antimycobacterial Activity of Essential Oils from BulgarianPharmaceutics · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The characteristic constituents of essential oils from aromatic plants have been widely applied as antimicrobial agents in the last decades. However, their mechanisms of action remain obscure, especially from the metabolic perspective. The aim of the study was to explore the antimicrobial effect and mechanism of menthone, a main component of peppermint oil, against methicillin resistant Methods: An integrated approach including the microbiology and the high-coverage lipidomics was applied. The changes of membrane properties were studies by the fluorescence and electron microscopical observations. The lipid profile was analyzed by ultra-high performance liquid chromatography coupled with quadruple Exactive mass spectrometry (UHPLC-QE-MS). The lipid-related key targets which were associated with the inhibitory effect of menthone against MRSA, were studied by network analysis and molecular docking. Results: Menthone exhibited antibacterial activities against MRSA, with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 3,540 and 7,080 μg/mL, respectively. The membrane potential and membrane integrity upon menthone treatment were observed to change strikingly. Further, lipids fingerprinting identified 136 significantly differential lipid species in MRSA cells exposed to menthone at subinhibitory level of 0.1× MIC. These metabolites span 30 important lipid classes belonging to glycerophospholipids, glycolipids, and sphingolipids. Lastly, the correlations of these altered lipids, as well as the potential metabolic pathways and targets associated with menthone treatment were deciphered preliminarily. Conclusion: Menthone had potent antibacterial effect on MRSA, and the mechanism of action involved the alteration of membrane structural components and corresponding properties. The interactions of identified key lipid species and their biological functions need to be further determined and verified, for the development of novel antimicrobial strategies against MRSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.