Evidence map›Paper›PMID 36721325›Full record

ArticleBioinformatics (Oxford, England)2023

PyGenePlexus: a Python package for gene discovery using network-based machine learning.

Christopher A Mancuso, Renming Liu, Arjun Krishnan

Open access · goldAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Christopher A MancusoDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-3081-2758
Renming LiuDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-6025-6492
Arjun KrishnanDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-7980-4110
Colorado School of Public Health · USMichigan State University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Resolving and understanding the genomic basis of heterogeneous complex traits and diseasesR35GM128765 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KRISHNAN, ARJUN · 2018 to 2022
$2.0M
Incorporating molecular network knowledge into predictive data-driven modelsF32GM134595 · NIGMS · MICHIGAN STATE UNIVERSITY · PI MANCUSO, CHRISTOPHER ANDREW · 2019 to 2022
$202k
NIGMS NIH HHS F32 GM134595NIGMS NIH HHS R35 GM128765NIH HHS R35 GM128765
6 · The paper itself

Abstract

summaryPyGenePlexus is a Python package that enables a user to gain insight into any gene set of interest through a molecular interaction network informed supervised machine learning model. PyGenePlexus provides predictions of how associated every gene in the network is to the input gene set, offers interpretability by comparing the model trained on the input gene set to models trained on thousands of known gene sets, and returns the network connectivity of the top predicted genes. AVAILABILITY AND IMPLEMENTATION: https://pypi.org/project/geneplexus/ and https://github.com/krishnanlab/PyGenePlexus. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

Computational BiologySoftwareGenetic Association StudiesMachine LearningSupervised Machine Learning

Identifiers

PMID36721325
PMCPMC9900208
OpenAlexW4318755679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.